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Investigating the impact of p53 and SIRT1 in the development of type 2 DM
Investigating the impact of p53 and SIRT1 in the development of type 2 DM through the treatment of prediabetic individuals by either nigetella salivata or Metformin
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| life style | Other | life style control only |
|
| Metformin | Active Comparator | Metformin 500 mg twice daily |
|
| Nigetella salivata | Experimental | NS 450 mg twice daily |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| life style | Other | life sryle control only |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with improved insulin resistance | Number of patients showing improved insulin resistance | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sherief Abd-Elsalam, ass. prof. | Contact | 00201147773440 | sheriefabdelsalam@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Eman SA Sawan, Msc | Tanta University - Faculty of Pharmacy | Principal Investigator |
| Sahar Hegazy, Prof | Tanta University - Faculty of Pharmacy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sherief Abd-Elsalam | Recruiting | Cairo | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34006388 | Derived | Mostafa TM, Hegazy SK, Elnaidany SS, Shehabeldin WA, Sawan ES. Nigella sativa as a promising intervention for metabolic and inflammatory disorders in obese prediabetic subjects: A comparative study of Nigella sativa versus both lifestyle modification and metformin. J Diabetes Complications. 2021 Jul;35(7):107947. doi: 10.1016/j.jdiacomp.2021.107947. Epub 2021 May 8. |
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| ID | Term |
|---|---|
| D008687 | Metformin |
| ID | Term |
|---|---|
| D001645 | Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
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| Metformin | Drug | metformin twice daily |
|
|
| Nigetella salivata | Drug | NS twice daily |
|
|
| Tarek Mostafa, ass. Prof. |
| Tanta University - Faculty of Pharmacy |
| Study Director |
| Sherin El-Nidany, MD | Tanta University-Faculty of pharmacy | Study Chair |