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| Name | Class |
|---|---|
| Bispebjerg Hospital | OTHER |
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Chronic Obstructive Lung Disease (COPD) is one of the leading death causes worldwide. COPD is a disease that is characterized by chronic inflammation which leads to irreversible damage of airways and lung tissue. This intervention investigates the effects of a diet high in protein and energy for the improvement of coughing capacity and lung function of COPD patients. The patients will be recruited as part of a lung rehabilitating programme which takes place in Bispebjerg and Hvidovre Hospital. The intervention group receives individual nutritional guidelines whereas the control group continues their usual diet. Blood tests will be performed at baseline and the end of the study. Other anthropometric measures include spirometry for lung function, hand grip strength and fat free mass to assess muscle waisting.
40 patients with COPD randomized to diet with protein 1.3 g/kg/day or habitual intake:
Primary endpoint (before-after): Leicester Cough Questionnaire Secondary endpoints: ADL-score, no. daily cough periods, development in FEV1 and FVC, hand-grib-strenght, use of respiratory medications, smoking, appetite, admissions to hospital, antibiotics and/or steroids, oxygen saturation, FFM (BIA), Coughs tests in spirometer and peak-flow-meter
Study period: 2 months
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention group | Experimental | 1.3 g protein per kg bodyweight per day for 8 weeks |
|
| Kontrol group | Active Comparator | habitual diet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High protein and energy diet | Dietary Supplement | Intervention group receives nutritional counseling to increase protein and energy in their diet to reach their estimated protein need (1.3 g/kg). Kontrol group continues their usual diet. |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement of coughing capacity of COPD patients | Measured by a validated danish version of Leicester Cough Questionnaire (1-7 points) | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Weight change | kg difference | 8 weeks |
| Oxygen saturation before and after treatment | Finger tip measurement - % of normal | 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Camilla Kieffer, stud scient | Contact | +4523252262 | camillakieffer@me.com | |
| Jens R Andersen, MD, MPA | Contact | +4523346654 | jra@nexs.ku.dk |
| Name | Affiliation | Role |
|---|---|---|
| Jens R Andersen, MD, MPA | Associate Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pulmonary Medicine, Bispebjerg Hospital | Copenhagen | 2400 | Denmark |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Randomized
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| Habitual Diet | Other | Patients continue their usual diet |
|
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |