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| Name | Class |
|---|---|
| Centre for Infectious Disease Research in Zambia | OTHER |
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The purpose of this Quality Improvement initiative is to reduce severe morbidity and mortality among premature infants through proven and cost-effective clinical management during the antenatal, intrapartum, and postpartum periods. In order to reduce neonatal mortality and morbidity due to preterm birth complications, health facilities must be able to identify and manage women in preterm labor, accurately administer medications, and provide high-quality postnatal care.
The purpose of this Quality Improvement initiative is to reduce severe morbidity and mortality among premature infants through proven and cost-effective clinical management during the antenatal, intrapartum, and postpartum periods. In order to reduce neonatal mortality and morbidity due to preterm birth complications, health facilities must be able to identify and manage women in preterm labor, accurately administer medications, and provide high-quality postnatal care.
The study will provide evidence of implementing a package of clinical interventions coupled with quality improvement and monitoring strategy aimed at reducing neonatal mortality in 3 resource-limited health facilities, leveraging on an existing strengthened birth registry to provide neonatal outcomes up to 28 days after delivery. Additionally, using a multifaceted approach through an interdisciplinary team, the investigators will identify the social and cultural barriers that contribute to home-based deliveries. These findings will be helpful to the Ministry of Health in shaping future policies regarding the scale-up of newborn care clinical protocols as part of Government's efforts to reducing neonatal mortality in Zambia.
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| Measure | Description | Time Frame |
|---|---|---|
| 10% relative risk reduction in 28-day neonatal mortality rate in preterm infants | Rate of 28-day neonatal mortality at the end of the study compared to that at baseline | Baseline to 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| 20% relative risk reduction in all-cause 7-day neonatal mortality in preterm infants | Rate of 7-day neonatal mortality at the end of the study compared to that at baseline | Baseline to 36 months |
| Factors that contribute to home and facility deliveries within the PREEMI facility catchment areas through the use of pre-determined questionnaire. |
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Inclusion Criteria:
Exclusion Criteria:
Pregnant women who seek antenatal care and delivery services at the selected 3 health facilities.
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Pregnant women who seek antenatal care and delivery services at the selected 3 health facilities.
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| Name | Affiliation | Role |
|---|---|---|
| Albert Manasyan, MD, MPH | University of Alabama at Birmingham | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chawama 1st Level Hospital, Chipata 1st Level Hospital, and George Clinic | Lusaka | 10101 | Zambia | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36048848 | Derived | Muttau N, Mwendafilumba M, Lewis B, Kasprzyk K, Travers C, Menon JA, Mutesu-Kapembwa K, Mangangu A, Kapesa H, Manasyan A. Strengthening Kangaroo Mother Care at a tertiary level hospital in Zambia: A prospective descriptive study. PLoS One. 2022 Sep 1;17(9):e0272444. doi: 10.1371/journal.pone.0272444. eCollection 2022. | |
| 33176718 |
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The study data will be shared upon a reasonable request to the study PI.
The data will be shared with the requesting investigator/entity.
For secondary analysis purposes or verification of publication results.
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| D007752 | Obstetric Labor, Premature |
| D066087 | Perinatal Death |
| ID | Term |
|---|---|
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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Number of study participants who delivered at home and at a health facility |
| Baseline to 36 months |
| University Teaching Hospital |
| Lusaka |
| 10101 |
| Zambia |
| Tembo T, Koyuncu A, Zhuo H, Mwendafilumba M, Manasyan A. The association of maternal age with adverse neonatal outcomes in Lusaka, Zambia: a prospective cohort study. BMC Pregnancy Childbirth. 2020 Nov 11;20(1):684. doi: 10.1186/s12884-020-03361-5. |
| D003643 | Death |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |