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The standard treatment for palmar hyperhidrosis is bilateral sequential thoracic sympathectomy. High rates of compensatory sweating due to the surgical procedure are described in the literature. In the search for a reduction in this side effect, it is possible that unilateral sympathectomy in the dominant side obtains acceptable results and leads to less compensatory sweating with improvement of the quality of life. The aim of this study it to compare the intensity of compensatory sweating due to the standard treatment, that is, bilateral sequential videothoracoscopic sympathectomy in relation to unilateral thoracic sympathectomy on the dominant side.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bilateral sympathectomy | Active Comparator | Bilateral sequential (one surgical procedure) videothoracoscopic R4 sympathectomy |
|
| Unilateral sympathectomy | Experimental | Unilateral videothoracoscopic R4 sympathectomy on the right (dominant) side |
|
| Contralateral sympathectomy | Experimental | Unilateral videothoracoscopic R4 sympathectomy on the left (contralateral) side |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bilateral sequential sympathectomy | Procedure | Bilateral videothoracoscopic sequential R4 sympathectomy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of sweating intensity | To utilize the HDSS questionnaire to assessment of sweating intensity change in patients with palmar hyperhidrosis treated by bilateral sequential thoracic sympathectomy | Change from baseline sweating to 6 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Change of sweating intensity | To utilize the HDSS questionnaire to assessment of sweating intensity change in patients with palmar hyperhidrosis submitted to unilateral sympathectomy on the dominant (right) side | Change from baseline sweating to 6 months after sympathectomy |
| Change of sweating intensity |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Quality of life | To utilize the HidroQOL questionnaire to evaluate the change in quality of life | Change from baseline quality of life to 6 months after surgery |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Niura N Hamiltopn, MD | Contact | +55 (11) 2661-5708 | niurinhaa@yahoo.com.br | |
| Nelson Wolosker, MD,PhD | Contact | nwolosker@yahoo.com.br |
| Name | Affiliation | Role |
|---|---|---|
| Miguel L Tedde, MD, PhD | Thoracic Surgeon, InCor, FMUSP | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Universitário da Universidade Federal do Amazonas | Recruiting | Manaus | Amazonas | Brazil |
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Participants will be randomized to be submitted to sequential bilateral sympathectomy or unilateral sympathectomy on the dominant side. After 4 to 6 months participants of the unilateral group can make the contralateral sympathectomy
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| Unilateral sympathectomy | Procedure | Unilateral videothoracoscopic R4 sympathectomy in dominant side (right side) |
|
| Contralateral sympathectomy | Procedure | Contralateral (left side) videothoracoscopic R4 sympathectomy |
|
To utilize the HDSS questionnaire to assessment of sweating intensity change in patients submitted to contralateral (left side) sympathectomy after unilateral sympathectomy on the dominant side |
| Change from baseline sweating to 6 months after surgery |
| Hospital Geral Dr. Cesar Cals | Recruiting | Fortaleza | Ceará | Brazil |
|
| Hospital Santa Isabel | Not yet recruiting | Salvador | Estado de Bahia | Brazil |
|
| Instituto Hospital de Base | Not yet recruiting | Brasília | Federal District | Brazil |
|
| Hospital Julia Kubitschek | Recruiting | Belo Horizonte | Minas Gerais | Brazil |
|
| Hospital Maternidade Terezinha de Jesus | Recruiting | Juiz de Fora | Minas Gerais | Brazil |
|
| Hospital Universitário Oswaldo Cruz | Recruiting | Recife | Pernambuco | Brazil |
|
| Hospital Universitário Pedro Ernesto | Recruiting | Rio de Janeiro | Rio de Janeiro | Brazil |
|
| Hospital Universitário Onofre Lopes | Recruiting | Natal | Rio Grande do Norte | Brazil |
|
| Hospital Geral de Caxias do Sul | Not yet recruiting | Caxias do Sul | Rio Grande do Sul | Brazil |
|
| ID | Term |
|---|---|
| D006945 | Hyperhidrosis |
| ID | Term |
|---|---|
| D013543 | Sweat Gland Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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