Evaluating the Effect of Inositol Supplementation in Overweight Children on Basal Insulin and Body Weight

Effects of Inositol Supplementation in Children With Excessive Body Weight and Insulin Resistance

Inositol in involved in the insulin pathway. In literature it has been demonstrated to improve insulin sensitivity and ovarian function in women affected by PCOS.

In a preliminary study conducted on obese children between 7 and 15 years, the investigators have demonstrated that Inositol administration (Myo-inositol 1100 mg + D-Chiro-inositol 27,6 mg + Folic Acid 400 μg) before a Glucose Oral Tolerance Test reduces the increase of insulin levels, particularly in subjects with basal insulin ≥ 15 uU/ml.

So the aim of this study is to evaluate the potential therapeutic effect of inositol, as non-pharmacologic agent, in preventing tipe II diabetes in children.

Inclusion Criteria:

• 8-18 years old
• overweight or obesity
• basal insulin ≥ 20 uU/ml

Exclusion Criteria:

• pubertal delay
• hypogonadism
• hypothyroidism or hyperthyroidism
• obesity-related genetic diseases