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Introduction: Pityriasis lichenoides (PL) is an inflammatory dermatitis of undetermined origin consisting of specific papular lesions reflecting an "indolent" lymphoproliferative state.
The current classification is confusing because it mixes semiological and chronological notions.
The objectives of this study are to better describe the clinical, epidemiological, histological, phenotypic and evolutionary aspects of PL in an adult population.
Methods: Investigators will perform a retrospective cohort study including patients with clinical and histological diagnosis of PL from the coding of the Department of Pathology of Henri-Mondor Hospital and from medical records and photographs of lesions if available, between January 2012 and August 2018. A follow-up telephone interviews will also be proposed to each patient to collect evolution data. Photographs will be systematically reviewed as well as cutaneous samples and a genomic analysis will be performed.
Conclusion: Investigators would like to better understand clinical, histological features and evolutionary aspects of PL in an adult population.
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| Measure | Description | Time Frame |
|---|---|---|
| To study clinical Aspects of Pityriasis Lichenoides on a large series of adult patients | Epidemiological and and clinical aspect description of the lesions from medical charts and photographs: age, sex, suspected trigger of the disease, past medical history, frequency of necrotic lesions, topography of lesions, fever, altered general conditions, treatment modalities of the flare. | It will be measured within 6 months of enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| To study histological features of Pityriasis Lichenoides | The histological description will make use of a centralized re-reading of the slides according to a standardized grid (appearance of the epidermis, type and topography of the dermal infiltrate, results of the immunolabelings etc ...). The investigators aim to investigate the frequency of patients with patterns of pityriasis lichenoides mimicking lymphomatoid papulosis or mycosis fungoides and to correlate the histological aspect with clinical lesions. |
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Inclusion Criteria:
Exclusion Criteria:
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Adults with Pityriasis Lichenoides
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Saskia ORO, Doctor | Contact | +33 1 49 81 25 36 | saskia.oro@aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Saskia ORO, Doctor | Assistance Publique Hôpitaux de Paris - CHU Henri Mondor - Créteil | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17010734 | Background | Bowers S, Warshaw EM. Pityriasis lichenoides and its subtypes. J Am Acad Dermatol. 2006 Oct;55(4):557-72; quiz 573-6. doi: 10.1016/j.jaad.2005.07.058. | |
| 29315771 | Background | Zang JB, Coates SJ, Huang J, Vonderheid EC, Cohen BA. Pityriasis lichenoides: Long-term follow-up study. Pediatr Dermatol. 2018 Mar;35(2):213-219. doi: 10.1111/pde.13396. Epub 2018 Jan 9. |
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DATAS ARE OWN BY ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, PLEASE CONTACT SPONSOR FOR FURTHER INFORMATION
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| ID | Term |
|---|---|
| D017514 | Pityriasis Lichenoides |
| D016410 | Lymphoma, T-Cell, Cutaneous |
| ID | Term |
|---|---|
| D017512 | Lichenoid Eruptions |
| D017444 | Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| It will be measured within 6 months of enrollment |
| To study molecular features of Pityriasis Lichenoides | number of clone T in the skin and in the blood. | It will be measured within 6 months of enrollment |
| To study the treatment during patients' monitoring | number of patients with need of a prolonged treatment | It will be measured within 6 months of enrollment |
| To study the duration of outbreak during patients' monitoring | the time to healing | It will be measured within 6 months of enrollment |
| To study the relapse during patients' monitoring | the number of relapses | It will be measured within 6 months of enrollment |
| To study the number of outbreaks during patients' monitoring | the number of outbreaks | It will be measured within 6 months of enrollment |
| 30325315 | Background | Lalevee S, Ortonne N, Hotz C, Schlemmer F, Beldi-Ferchiou A, Delfau-Larue MH, Wolkenstein P, Chosidow O, Ingen-Housz-Oro S. Febrile ulceronecrotic Mucha Habermann disease mimicking aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma: a diagnostic challenge. Eur J Dermatol. 2018 Dec 1;28(6):834-835. doi: 10.1684/ejd.2018.3410. No abstract available. |
| 25816855 | Background | Geller L, Antonov NK, Lauren CT, Morel KD, Garzon MC. Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options. Pediatr Dermatol. 2015 Sep-Oct;32(5):579-92. doi: 10.1111/pde.12581. Epub 2015 Mar 26. |
| 17456915 | Background | Nair PS. A clinical and histopathological study of pityriasis lichenoides. Indian J Dermatol Venereol Leprol. 2007 Mar-Apr;73(2):100-2. doi: 10.4103/0378-6323.31894. |
| 17298104 | Background | Khachemoune A, Blyumin ML. Pityriasis lichenoides: pathophysiology, classification, and treatment. Am J Clin Dermatol. 2007;8(1):29-36. doi: 10.2165/00128071-200708010-00004. |
| 29210716 | Background | Zaaroura H, Sahar D, Bick T, Bergman R. Relationship Between Pityriasis Lichenoides and Mycosis Fungoides: A Clinicopathological, Immunohistochemical, and Molecular Study. Am J Dermatopathol. 2018 Jun;40(6):409-415. doi: 10.1097/DAD.0000000000001057. |
| 27031678 | Background | Sibbald C, Pope E. Systematic review of cases of cutaneous T-cell lymphoma transformation in pityriasis lichenoides and small plaque parapsoriasis. Br J Dermatol. 2016 Oct;175(4):807-9. doi: 10.1111/bjd.14605. Epub 2016 Jun 20. No abstract available. |
| 26566599 | Background | Vonderheid EC, Kadin ME, Telang GH. Commentary about papular mycosis fungoides, lymphomatoid papulosis and lymphomatoid pityriasis lichenoides: more similarities than differences. J Cutan Pathol. 2016 Apr;43(4):303-12. doi: 10.1111/cup.12653. Epub 2015 Dec 22. No abstract available. |
| D010267 | Parapsoriasis |
| D010915 | Pityriasis |
| D016399 | Lymphoma, T-Cell |
| D008228 | Lymphoma, Non-Hodgkin |
| D008223 | Lymphoma |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |