Lipopolysaccharide Metabolism and Identification of Potential Biomarkers Predictive of Graft-versus-host Disease After Allogeneic Stem Cell Transplantation

Study of Lipopolysaccharide Metabolism for Identification of New Biomarkers Predictive of Graft-versus-host Disease After Allogeneic Stem Cell Transplantation

This study is designed to assess the hypothesis that the lipopolysaccharide (LPS) activity index can be quantified early after transplantation, as well as the the PhosphoLipid Transfer Protein (PLTP) activity and these both biological variables are independent variables for predicting the risk of severe Graft versus Host Disease (GVHD).

Inclusion Criteria:

• Hematologic malignancy in complete remission
• Patients eligible for allogeneic hematopoietic cell transplantation from a related or unrelated donor and after myeloablative or non-myeloablative conditioning.
• Regular follow-up in the center

Exclusion Criteria:

• Treatment with a statin in progress
• Umbilical cord blood transplantation
• Hemoglobin level less than or equal to 8g / dl
• Known chronic inflammatory bowel disease or gastroenteritis at the time of inclusion.
• Chronic enteropathy with Clostridium Difficile