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| Name | Class |
|---|---|
| Baxter Healthcare Corporation | INDUSTRY |
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Randomized Clinical Trial following the evaluation of the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.
Randomized Clinical Trial to evaluate the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.
Secondary Endpoint: Among secondary endpoints we will evaluate clinical variables such emergence and recovery characteristics (time to extubation and time to emergence-open eyes and response to verbal command), the need for postoperative mechanical ventilation, the post-anesthesia recovery score and ICU length of stay.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group sevoflurane | Active Comparator | Administration under labelling conditions |
|
| Group desflurane | Experimental | Administration under labelling conditions |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sevoflurane | Drug | administration of sevoflurane |
| |
| Desflurane |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Biochemical parameters | NGAL in urine | All these parameters will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | Cystatin C(mg/L) in plasma | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | Creatinine(mg/dL) in plasma | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | sodium(mMol/L) in plasma | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | potassium(mMol/L) in plasma | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | Chloride(mMol/L) in plasma | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | albumin(g/dL) in plasma | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Measure | Description | Time Frame |
|---|---|---|
| Need for postoperative mechanical ventilation | hours of mechanical ventilation in ICU | 24 hours |
| ICU length of stay | hours in ICU | up to 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Begoña Quintana, PhD | Hospital General Universitario Gregorio Marañón | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital general universitario Gregorio Marañón | Madrid | 28007 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41079741 | Derived | Arnalich-Montiel A, Barrio-Perez IM, Burgos-Santamaria A, Fernandez-Riveira C, Lazaro A, Gonzalez-Nicolas MA, Rio J, Bellon JM, Canal MI, Ligero JM, Quintana-Villamandos B. Influence of the type of volatile anesthetic on the development of acute kidney injury after endovascular repair of aortic aneurysm: a randomized controlled trial (DESEVAR study). Front Pharmacol. 2025 Sep 25;16:1660359. doi: 10.3389/fphar.2025.1660359. eCollection 2025. |
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| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D000077149 | Sevoflurane |
| D000077335 | Desflurane |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
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| Drug |
administration of Desflurane |
|
| Change in Biochemical parameters | osmolarity(mOsm/Kg) in plasma | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | NGAL in plasma | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | Creatinine(mg/dL) in urine | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | sodium(mMol/L) in urine | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | potassium(mMol/L) in urine | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | Chloride(mMol/L) in urine | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | albumin(g/dL) in urine | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| Change in Biochemical parameters | osmolarity(mOsm/Kg) in urine | will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups |
| anesthetic recovery | time to extubation(minutes). | These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded at baseline and after surgery. time frame upto 1 hour(stimated) |
| anesthetic recovery | time to spontaneous eye opening(minutes) | These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded after surgery. timeframe up to 1 hour(stimated). |
| anesthetic recovery | time until first response to verbal commands(minutes) | These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded after surgery. timeframe up to 1 hour(stimated). |
| anesthetic recovery | The post-anesthesia recovery score ( Modified Aldrete score) (0-1-2 from worse to better) | These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded at baseline and after surgery. timeframe 1 hour(stimated) |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D006846 |
| Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D005019 | Ethyl Ethers |