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Investigation of how a single session of an attentional filter exercise of distractor inhibition combined with tDCS modulates cognitive functions like working memory, decision making and attentional control.
The study is designed as a between subject design with two groups defined by real or sham tDCS. The distractor inhibition exercise is conducted under either sham or real tDCS. Cognitive performance is assessed pre and post tDCS application, complemented by a short-termed follow-up on a consecutive day. Interindividual working memory capacity at baseline is taken into consideration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tDCS group | Experimental | one session of computerized change detection attentional filter exercise (selective attention) combined with real tDCS |
|
| sham group | Sham Comparator | one session of computerized change detection attentional filter exercise (selective attention) combined with sham tDCS |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial direct current stimulation (tDCS) | Device | sham or real tDCS for 10 minutes of 1.5 milliampere (mA) tDCS targeting the prefrontal and the posterior parietal cortex |
|
| Measure | Description | Time Frame |
|---|---|---|
| Performance change in computerized attentional filter exercise | attentional filtering performance (in % correct), effects of distractor interference for different set sizes | 45 minutes on 1st day (pre) and on consecutive day (post) |
| Reaction change in computerized attentional filter exercise | reaction times (in milliseconds), effects of distractor interference for different set sizes | 45 minutes on 1st day (pre) and on consecutive day (post) |
| Performance change in working memory and filtering performance | Working memory and filtering performance (in % correct), effects of distractor interference for different set sizes | 30 minutes per pre-assessment, post assessment directly after intervention and short-termed follow-up on the consecutive day |
| Reaction change in working memory and filtering performance | reaction times (in milliseconds), effects of distractor interference for different set sizes | 30 minutes per pre-assessment, post assessment directly after intervention and short-termed follow-up on the consecutive day |
| Measure | Description | Time Frame |
|---|---|---|
| Spatial Span | computerized spatial span forward and backward | 10 minutes per pre-assessment and short-termed follow-up on the consecutive day |
| Iowa Gambling Task | Decision making performance |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marlen Schmicker | Contact | +49 3916724505 | marlen.schmicker@dzne.de |
| Name | Affiliation | Role |
|---|---|---|
| Notger Müller, Prof. Dr. | German Center for Neurodegenerative Diseases (DZNE) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| German Center for Neurodegenerative Diseases | Recruiting | Magdeburg | Saxony-Anhalt | 39120 | Germany |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| 7 minutes per pre-assessment, post assessment directly after intervention and short-termed follow-up on the consecutive day |
| Trait-Anxiety | Assessment of trait anxiety via State-Trait-Anxiety-Inventory on first day | 2 minutes on first day |
| State-Anxiety | Daily assessment of state anxiety via State-Trait-Anxiety-Inventory at the beginning of each testing day | 2 minutes on first and consecutive day |
| Assessment of Sleep Quality | daily questionnaire assessing subjective rating of sleep of the previous night on 5- to 7-point Likert format and open questions (subjective quality of sleep, current fatigue, duration of sleep); no total score | 10 minutes on first and consecutive day |
| Daily Performance Questionnaires | self developed questionnaire assessing subjective performance in tested paradigms (5-point Likert format); no total or sub score; Question 1: How difficult would you rate the task? (lowest (1) = very difficult; highest (5) = very easy) Question 2: Do you think your performance changed in the course of the task? (lowest (1) = strongly worsened; highest (5) = strongly improved) | 5 minutes on first and consecutive day |
| Daily Strategy Questionnaires | reporting of used strategies in tested paradigms (open questions; subjects reported in written notes); self developed questionnaire for qualitative analyses of task demands; no scores; Question: Did you use a strategy? If so, please explain shortly. | 5 minutes on first and consecutive day |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |