Modafinil to Prevent Postoperative Cognitive Decline

An Examination of the Effects of Modafinil (Provigil) or Placebo on Neurocognitive Testing After General Anesthesia for Non-Cardiac Surgery in an Older Population

Postoperative cognitive dysfunction is a well-recognized complication of surgery. The aim of the study is to investigate whether cognitive dysfunction is reduced by the use of modafinil as shown by neurocognitive testing.The treatment effects will be evaluated compared to placebo as well as a non-surgical group.

Inclusion Criteria:

• American Society of Anesthesiologists class I or II

• Elective surgery

• Surgery requiring general anesthesia

  4.) Control Group will be-females & males 65 and older not scheduled for any surgical procedures for at least a 3 month period.

Exclusion Criteria:

• Neurosurgery
• Cardiac surgery
• Narcotic or illicit drug abuse
• Chronic opioid use
• Chronic use of anxiolytics
• History of pulmonary disease
• C02 retention
• Sleep apnea
• Obesity