By the method of multi-mode Magnetic Resonance Imaging, 5 patients with knee osteoarthritis are selected in this trial to observe the possible differences in the brain structure and function from the 5 healthy volunteers.

In this study, 5 patients with knee osteoarthritis and 5 healthy volunteers were selected. The degree of pain is evaluated via visual analogue pain scale (VAS). The emotional state is evaluated by Hamilton anxiety scale (HAMA) or Hamilton depression scale (HAMD). The patients and healthy volunteers who meet the include criteria are include in the research. Then the spontaneous brain electrical activity is collected by multimodal brain magnetic resonance imaging technology. The spontaneous brain electrical activity is analyzed to find the differences between knee osteoarthritis patients and healthy volunteers. Further analysis of resting brain functional connectivity and information exchange changes in multifunctional areas, in order to elaborate the central mechanism of pain and emotion modulation.

Inclusion Criteria:

The experimental group was selected as:

• Meet the above diagnostic criteria.
• VAS scale score > 4 points.
• HAMA score > 14 or HAMD score > 17 points.
• Agree to participate in the survey and submit an informed consent form.

The control group was selected as:

• Healthy volunteers who exclude knee osteoarthritis.
• VAS scale score ≤ 4 points.
• HAMA score ≤14 or HAMD score ≤ 17 points.
• Agree to participate in the survey and submit an informed consent form

Exclusion Criteria:

• Rheumatoid arthritis, psoriatic arthritis, gouty arthritis, bone erosion, bone tuberculosis, bone tumor patients.
• Clear diagnosis of traumatic meniscus, cruciate ligament, collateral ligament injury history and patients with history of knee trauma in the past six months.
• Have a heavier heart, brain and other medical conditions and poor overall health.
• In pregnancy, pregnancy or lactation.
• Taking antidepressant and anxiety drugs.
• Participated in other clinical studies within 2 months prior to the start of the study.
• The patient or his licensor is unwilling to sign a written informed consent or is unwilling to follow the research protocol.

This study is a single-center randomized controlled clinical trial. It is expected to enroll 5 patients with knee osteoarthritis in the third affiliated hospital of zhejiang university of traditional Chinese medicine and recruit 5 healthy volunteers at the same time.