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The purpose of this study is to determine the sleep patterns of subjects with or without sleep disturbances (insomnia, sleep apnea) and compare these findings with their previous FDG/PIB PET, structural MRI and brain blood flow scams performed during their participation in the Following studies 'Alzheimer's Disease Core Center (ADCC) Clinical Evaluation' (IRB: 2942), MRI Progression Markers of Cognitive Decline in the Elderly' (IRB:09-0586), or 'Imaging Neuro inflammation in Alzheimer's Disease with [11C] Arachidonic Acid (AA) and PET'(IRB: 10-00442).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mild Cognitive Impairment (MCI) | Patients with clinical dementia rating of 0.5 or a global deterioration scale of 3. |
| |
| Normal Cognition (NL) | Clinical Dementia Rating [CDR] of 0 or Global Deterioration Scale [GDS] of 1-2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Structural 3T MRI | Diagnostic Test | measures of global and hippocampal atrophy) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Decreased cerebral blood flow (CBF) | Measured by perfusion MRI | 1 Week |
| Measure of vasoreactivity to CO2 (VRCO2) | subjects will breath through a respiratory tube and CO2 will be meaured | 1 Week |
| Increase in cortical AB plaque burden | Measured by PIB PET | 1 Week |
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Inclusion Criteria:
Exclusion Criteria:
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80 cognitively healthy subjects (normal or MCI) previously enrolled in Alzheimer's Disease Core Center (ADCC) and CBH studies who have agreed to be contacted about future research studies will be asked to additionally participate in this study. The age range of the subjects will be of 55-90 years based on the incidence of dementia in middle age and elder adults.
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| Name | Affiliation | Role |
|---|---|---|
| Ricardo Osorio, MD | NYU Langone Health | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NYU Langone Medical Center | New York | New York | 10016 | United States |
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| ID | Term |
|---|---|
| D012893 | Sleep Wake Disorders |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| MRI Based Perfusion Imaging | Diagnostic Test | brain blood flow |
|
| VR-CO2 MRI Scans | Diagnostic Test | reduced vaso reactivity to carbon dioxide |
|
| D001523 | Mental Disorders |