Evaluation of HbA1c Levels and Ovarian Reserve and Type 1 Diabetes

Evaluation of HbA1c Levels and Ovarian Reserve in Patients With Type 1 Diabetes Diagnosis

The human ovary is the target of an autoimmune attack, usually in organ or non-specific autoimmune disorders. Serum anti-Müllerian hormone (AMH) levels decrease early in menopause and menopause is seen in women with type 1 diabetes mellitus (DM1) at a young age. DM1 is aimed to show DM1 relationship with ovarian reserve based on the assumption that it will have lower AMH levels than controls, secondary to bad glycemic control and autoimmune attack in women.

The study was designed prospectively. Ovarian functions in healthy volunteer women and patients who use DM1 diagnosed between 18-40 years old will be examined. Gonadotropin and AMH levels will be measured in follicular phase. To calculate the number of antral follicles (AFC) and ovarian volume, ultrasound will be looked at. Fasting and satiety blood glucose, HbA1c and C-peptide levels will be evaluated.

Inclusion Criteria:

• female patients between 18 and 40 years of age who had consent and had gynecological examination in our polyclinic;
• study group for patients with type 1 diabetes mellitus healthy volunteers control group

Exclusion Criteria:

• Other endocrine and / or autoimmune disorders, polycystic ovary syndrome (PCOS) and
• previous surgery, which may reduce ovarian reserves;
• medical and / or radiotherapy