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Researchers are evaluating quality of life in pulmonary hypertension subjects using the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT) Questionnaire and assessing the questionnaires' performance with regard to relationship to other markers of disease severity, response to treatment, and outcome in a clinical practice setting.
Subjects will be recruited from among those seen at the Mayo Pulmonary Hypertension Clinic. The PAH-SYMPACT questionnaire will be administered either in written form or by telephone interview.
On the second 100 patients implement a standardized palliative care referral program for patients with Group 1 and 3 PH and high SYMPACT scores> 1.0.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| usual care | The patient will be seen in the PH clinic and will be approached to consent and participate in the SYMPACT trial. They will not be randomized to palliative care. | ||
| palliative care | The patient will be seen in the PH clinic and will be approached to consent and participate in the SYMPACT trial. Based on the patients in Group 1 and 3 PH and a high SYMPACT score> 1.0 in any domain they will be randomized to receive standard care or a palliative care initial consult. |
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| Measure | Description | Time Frame |
|---|---|---|
| Quality of life in pulmonary hypertension subjects | Measured using the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT) Questionnaire using a scale of 0=no, 1=mild, 2=moderate, 3=severe, and 4=very severe | Baseline |
| Quality of life in pulmonary hypertension subjects | Measured using the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT) Questionnaire using a scale of 0=no, 1=mild, 2=moderate, 3=severe, and 4=very severe | 14 months |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects will be recruited from among those seen at the Mayo Pulmonary Hypertension Clinic.
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| Name | Affiliation | Role |
|---|---|---|
| Hilary M DuBrock, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42164136 | Derived | DuBrock HM, Strand J, Rhee L, Christensen K, Frantz RP. A Randomized Controlled Trial of Specialty Palliative Care to Improve Health-Related Quality of Life in Pulmonary Arterial Hypertension. Pulm Circ. 2026 May 18;16:e70321. doi: 10.1002/pul2.70321. eCollection 2026 Jun. |
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| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
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| D002318 |
| Cardiovascular Diseases |