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This study aims to investigate the role of uNK cells and the association with prednisolone.
Glucocorticoids prednisolone is considered as a potential therapy in women with recurrent miscarriage. However, the evidence for treatment with prednisolone is still inconclusive and the relevant mechanism merits further investigations.
The participants will be invited to take prednisolone oral 10 mg/day and attend our outpaitent clinic to be performed endometrial biopsy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| prednisolone | Experimental | prednisolone oral 10 mg/day from day one of the subsequent menstrual cycle to day LH plus 7. Women will be then given a tailing off dose of 5 mg/day for 3 days followed by 2 mg/day for 3 days and then 1 mg/day for 3 days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Prednisolone | Drug | prednisolone oral 10 mg/day from day one of the subsequent menstrual cycle to day LH 7 of that cycle. Then, the participants will be given a tailing off dose of 5 mg/day for 3 days followed by 2 mg/day for 3 days and then 1 mg/day for 3 days. |
| Measure | Description | Time Frame |
|---|---|---|
| the number of uNK cells | to investigate the association between uNK cells and prednisolone | at the 1 day of endometrial biopsy |
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Inclusion Criteria:
Exclusion Criteria:
This study is going to investigate the association between uterine natural killer cells and prednisolone. Therefore, only female will be recruit
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Stacey Wong, BSc | Contact | 85235051764 | staceywong@cuhk.edu.hk | |
| Pui Wah Jacqueline Chung, MBBS | Contact | 85235051764 | jacquelinechung@cuhk.edu.hk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Chinese University of Hong Kong | Recruiting | Hong Kong | Hong Kong |
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| ID | Term |
|---|---|
| D000026 | Abortion, Habitual |
| ID | Term |
|---|---|
| D000022 | Abortion, Spontaneous |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D011239 | Prednisolone |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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The participants will be invited to take prednisolone oral 10 mg/day and attend our outpaitent clinic to be performed endometrial biopsy.
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| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |