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This study is intended to investigate the safety and efficacy of ω-3 polyunsaturated fatty acid-based parenteral nutrition (PN) for patients with Crohn's disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | parenteral nutrition without ω-3 polyunsaturated fatty acid |
|
| ω-3 fatty acid | Experimental | parenteral nutrition with ω-3 polyunsaturated fatty acid |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ω-3 polyunsaturated fatty acid | Drug | CD patients are divided into two groups, which include with and without ω-3 polyunsaturated fatty acid-based PN (0.1-0.2g/kg/d). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of Postoperative complications | postoperative complications after surgery for Crohn's Disease according to clavien-dindo system | postoperative 1-30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Length of postoperative hospital stay | postoperative hospital stay after surgery for Crohn's Disease | from surgery to discharge |
| Blood Concentration of IL-6 | Blood Concentration of IL-6 after surgery |
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Inclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wei Zhou, MD PHD | Contact | 13588706479 | zhouw@srrsh.com |
| Name | Affiliation | Role |
|---|---|---|
| Xiujun Cai | Sir Run Run Shaw Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sir Run Run Shaw hospital | Recruiting | Hangzhou | Zhejiang | 310016 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38569774 | Derived | Ge X, Liu H, Wu Y, Liu W, Qi W, Ye L, Cao Q, Lian H, Bai R, Zhou W. Parenteral n-3 polyunsaturated fatty acids supplementation improves postoperative recovery for patients with Crohn's disease after bowel resection: a randomized, unblinded controlled clinical trial. Am J Clin Nutr. 2024 Apr;119(4):1027-1035. doi: 10.1016/j.ajcnut.2023.12.022. Epub 2024 Feb 19. |
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Data collection from 2019-3 to 2020-9
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| ID | Term |
|---|---|
| D003424 | Crohn Disease |
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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|
| Intestinal surgery for Crohn's Disease | Procedure | Patients receive bowel resection due to complications of Crohn's Disease |
|
| postoperative 1, 3, and 6 day |
| Blood Concentration of TNF-α | Blood Concentration of TNF-α after surgery | postoperative 1, 3, and 6 day |
| Blood Concentration of IL-1β | Blood Concentration of IL-1β after surgery | postoperative 1, 3, and 6 day |
| Blood Concentration of albumin | Blood Concentration of albumin after surgery | postoperative 1, 3, and 6 day |
| Blood Concentration of C-reactive protein | Blood Concentration of C-reactive protein after surgery | postoperative 1, 3, and 6 day |
| Blood White blood cell level | Blood White blood cell level after surgery | postoperative 1, 3, and 6 day |
| D007410 | Intestinal Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |