Clinical and radiographic evaluation of injectable platelet rich fibrin (i-PRF) and demineralized freeze-dried bone allograft (DFDBA) compared to demineralized freeze-dried bone allograft (DFDBA) alone in management of intraosseous defects in stage III periodontitis patients.

Intraosseous defects are defined by the apical location of the periodontal pocket to the alveolar crest. In a recent radiographic study employing cone-beam computed tomography, a high prevalence of intraosseous defects 83% has been reported. Treatment of intraosseous defects is clinically challenging, as they often require complex regenerative periodontal therapy. Current regenerative techniques often employed in treatment of intraosseous defects demonstrate variation in improvement of clinical outcomes and degree of periodontal regeneration achieved.

Inclusion Criteria:

1. Type III periodontitis patient having at least one tooth with 2-wall, 3-wall, or combined 2- to 3-wall intraosseous defect ≥ 3 mm in depth (assessed by bone sounding, radiographic examination) with clinical attachment level ≥ 5 mm and pocket depth ≥ 6 mm.
2. Defect not extending to a root furcation area
3. Vital teeth
4. Non-smokers.
5. No history of intake of antibiotics or other medications affecting the periodontium in the previous 6 months.
6. No periodontal therapy carried out in the past 6 months.
7. Able to sign an informed consent form.
8. Patients age between 25 and 50 years old.
9. Patients who are cooperative, motivated, and hygiene conscious.
10. Systemically free according to Cornell Medical Index

Exclusion Criteria:

1. Pregnancy or breast feeding
2. The presence of an orthodontic appliance
3. Teeth mobility greater than grade I

Due to the type of intervention, only the outcome assessor and the statistician will be blinded.