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The primary aim of the current research project is to determine whether the TMAO concentration in the blood can serve as a prognostic indicator of myocardial infarction.
The hypothesis is that in patients with recent myocardial infarction, TMAO concentration in blood is higher than in patients undergoing scheduled coronarography.
To the study will be included volunteers - patients with stable angina (SA), who were scheduled for conventional coronary angiography, and patients with acute coronary syndrome (ACS) who were admitted to the hospital with chest pain and undergoing coronography surgery. Blood samples will be taken from volunteers once - before the coronography surgery by qualified medical personnel.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute Coronary Syndrome (ACS) | Patients with STEMI or NSTEMI infarction, who were admitted to the hospital with chest pain. |
| |
| Stable Angina (SA) | Patients with stable angina who were scheduled for conventional coronary angiography. |
| |
| Control Group (CON) | Healthy control group responding by age and gender to examined groups. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| plasma samples collection | Diagnostic Test | Trimethylamine N-oxide (TMAO) concentration will be determined in plasma samples |
|
| Measure | Description | Time Frame |
|---|---|---|
| Trimethylamine-N-oxidec(TMAO) blood concentration | TMAO concentration determined by the ultra-performance liquid-chromatography tandem mass spektrometry (UPLC-MS/MS). | Immediately before coronography. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients from the Pomeranian Cardiology Centers in Wejherowo
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| Name | Affiliation | Role |
|---|---|---|
| Robert A Olek, PhD | University of Physical Education and Sport in Gdansk | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Physical Education and Sport | Gdansk | Pomeranian Voivodeship | 80-336 | Poland |
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| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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plasma