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| ID | Type | Description | Link |
|---|---|---|---|
| 2018-A03343-52 | Other Identifier | ANSM |
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| Name | Class |
|---|---|
| MINAPATH Développement | OTHER |
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Hip arthroplasty is a treatment widely used in most inflammatory, traumatic and degenerative conditions of this joint. The longevity of implants may be disappointing in some cases, despite the promising results obtained during in vitro simulations. Early loco-regional or systemic dissemination, known since the 1990s, of wear particles from these prosthesis may reduce their life span.
The analysis of the particles in the synovial fluid and in the articular tissues by electron microscopy after digestion or directly by optical microscopy, will improve the knowledge on the mechanisms of wear.
This category 3 study is based on the case-control model and will be conducted in a national reference center (hospital la Croix-Rousse- Lyon). It will include a population of adult patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hip prosthesis metal/polyethylene in simple mobility |
| ||
| hip prosthesis metal/polyethylene in double mobility |
| ||
| hip prosthesis ceramic/polyethylene in simple mobility |
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| hip prosthesis ceramic/polyethylene in double mobility |
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| Primary implanted hip prosthesis |
| ||
| metal / metal prosthesis removed |
| ||
| ceramic / ceramic prosthesis removed |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hip prosthesis removed metal / polyethylene, simple mobility | Procedure | Patients are hospitalized in order to change their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by metal/polyethylene. It's a simple mobility The aim is to define the types of particles that cause the most tissue inflammation |
| Measure | Description | Time Frame |
|---|---|---|
| types of particles that cause the most tissue inflammation | Types of wear particles most found in patients whose tissues are classified as inflammatory. The particles can be classified by size, shape, material and type of original prosthesis. | day of surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Patients will be having a surgery for the resumption of a hip prosthesis or for a first implantation
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| Name | Affiliation | Role |
|---|---|---|
| Cécile Batailler, Dr | Hospices Civils de Lyon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Edouard Herriot | Lyon | 69003 | France | |||
| Hôpital de la Croix Rousse |
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| hip prosthesis removed metal / polyethylene, double mobility | Procedure | Patients are hospitalized in order to change their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by metal/polyethylene. It's a double mobility. The aim is to define the types of particles that cause the most tissue inflammation |
|
| hip prosthesis removed ceramic/ polyethylene, simple mobility | Procedure | Patients are hospitalized in order to change for their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by ceramic/polyethylene. It's a simple mobility. The aim is to define the types of particles that cause the most tissue inflammation |
|
| hip prosthesis removed ceramic/ polyethylene, double mobility | Procedure | Patients are hospitalized in order to change their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by ceramic/polyethylene. It's a double mobility. The aim is to define the types of particles that cause the most tissue inflammation. |
|
| Primary implanted hip prosthesis | Procedure | Patients are hospitalized in order to have a first hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The patients will be received a first prosthesis. |
|
| hip prosthesis removed metal/metal | Procedure | Patients are hospitalized in order to change their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by metal/metal. The aim is to define the types of particles that cause the most tissue inflammation |
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| hip prosthesis removed ceramic/ceramic | Procedure | Patients are hospitalized in order to change their hip prosthesis at the hospital "la Croix-Rousse" in Lyon. Patients have to complete before the surgery a survey on occupational and environmental exposures to mineral dust. The prosthesis removed is composed by ceramic/ceramic. The aim is to define the types of particles that cause the most tissue inflammation |
|
| Lyon |
| 69004 |
| France |
| ID | Term |
|---|---|
| D020959 | Polyethylene |
| D008670 | Metals |
| D002516 | Ceramics |
| ID | Term |
|---|---|
| D011095 | Polyethylenes |
| D011090 | Polyenes |
| D000475 | Alkenes |
| D006839 | Hydrocarbons, Acyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D010969 | Plastics |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D001697 | Biomedical and Dental Materials |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
| D007287 | Inorganic Chemicals |
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