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A multicenter, retrospective, real world study of Lapatinib among Metastatic Breast Cancer (MBC) Patients in Clinical Practice.
This study collected patients used Lapatinib-base therapy among MBC, and tried to figure out if there was difference between single anti-Her2 treatment and dual anti-Her2 treatment. Furthermore, this study investigated the treatment after Lapatinib.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Continuing Lapatinib | Patients continued using treatment containing Lapatinib after progression on Lapatinib. | ||
| Change HER-2 treatment | Patients changed to another HER-2 targeted treatment after progression on Lapatinib (ado-trastuzumab emtansine, trastuzumab, etc.). | ||
| Lapatinib plus capetabine | Patients used lapatinib plus capetabine. | ||
| Lapatinib plus Trastuzumab and one chemotherapy | Patients used lapatinib plus trastuzumab and one chemo regimen. |
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| Measure | Description | Time Frame |
|---|---|---|
| PFS | Progression free survival | 6 weeks |
| Number of participants with treatment-related adverse events as assessed by Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v4.0) | 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Patients diagnosed with breast cancer (according to International Classification of Diseases-10, ICD-10) with confirmed metastasis, regardless of being de novo diagnosed or progressed from a non-metastatic stage.
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| Name | Affiliation | Role |
|---|---|---|
| Biyun Wang, Professor | Fudan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fudan University Shanghai Cancer Center | Shanghai | Shanghai Municipality | 200032 | China |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| D017437 |
| Skin and Connective Tissue Diseases |