An intervention study to investigate the effect of B-vitamin supplementation for 2-years on bone health. This is a dual centre (UCD and University of Ulster) 2-year randomised, placebo controlled, double blind intervention.

Osteoporosis is a major public health issue, especially among older adults. The condition is widespread, with an estimated 1 in 2 women and 1 in 5 men over the age of 50 years expected to have an osteoporotic fracture. The associated health care costs are considerable and growing as the population of older adults increases. Furthermore, osteoporotic fractures are associated with loss of independence and risk of further fractures and health problems for the individual. Given these negative impacts, new approaches to help maintain better bone health in older age are urgently needed.

Vitamin D and calcium have well established protective roles, however, other evidence links certain B vitamins with bone health. This study will investigate the effect of B-vitamin supplementation over a two year period at two centres (UCD and University of Ulster)

Inclusion Criteria:

• 50 years and over
• Generally healthy, free living in the community
• Males and females (post menopausal and not taking HRT)

Exclusion Criteria:

• Currently taking a supplement containing B vitamins
• Currently consuming >4 portions of foods fortified with B vitamins per week
• Currently taking drugs known to interfere with folate/ B-vitamin metabolism
• Have a condition of the gastrointestinal system (such as coeliac disease/ chron's disease, ulcerative colitis) or liver disease (hepatitis and NAFLD)
• Be unable to consent to participate
• Be currently involved in another research study

2 year randomised, placebo controlled, double blinded intervention