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Open surgery on the abdominal aorta is a high risk procedure associated with an intravascular volume blood loss and thereby, with high requirement for blood and blood product transfusion.
The aim of this study was to establish the rate for allogenic blood transfusion (ABT) during elective open abdominal aortic surgery and find parameters associated with ABT requirements.
Two distinct clinical entities affect the abdominal aorta: abdominal aortic aneurysm (AAA) and aortoiliac occlusive disease (AIOD). These are multifactorial vascular disorders caused by complex genetic and environmental factors. Older patients with more comorbidity are often affected. Open abdominal aortic surgery is associated with high mortality rate. Even in specialised institutions it varies from 2 to 5%. Similar results can be compared to mortality for coronary artery bypass grafting. This reflects the complexity of the surgery and the general health of those patients. It is associated with intravascular volume blood loss and, thereby, with a high requirement for blood and blood products transfusion. Allogenic blood transfusion (ABT) has been associated with an increased risk of tumour recurrence, postoperative infection, acute lung injury, perioperative myocardial infarction, postoperative low-output cardiac failure, and increased mortality.
In the last decades, multiple strategies have been undertaken to prevent massive intraoperative blood loss during elective surgery and allogenic blood transfusion requirement. One of the method advocates a preoperative increase in red blood cells level using B12, folic acid and iron supplements or with erythropoietin usage. Other methods involve the optimisation of surgical technique and the use of a machine for intraoperative blood salvage, known as "cell saver".
The aim of this study was to establish the rate for ABT during elective open abdominal aortic surgery, find parameters associated with ABT requirements, and optimise the investigators hospital's maximum surgical blood ordering schedule (MSBOS).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Transfused group (TR) | Group received allogenic blood transfusion (ABT) alongside with autologous blood from intraoperative cell saver (ICS) during elective open abdominal aortic surgery. |
| |
| Non-transfused (non-TR) | Group received only autologous blood from intraoperative cell saver (ICS) during elective open abdominal aortic surgery. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Allogenic blood transfusion (ABT) | Other | During elective open aortic surgery, the autologous blood from ICS was processed and re-transfused in all patients. However, TR group additionally received ABT. |
| Measure | Description | Time Frame |
|---|---|---|
| Overall ABT requirement | Overall ABT requirement (in %) during elective abdominal aortic surgery with the use of ICS for intraoperative blood salvage and autologous transfusion. | Retrospective analysis, 6-year period |
| Measure | Description | Time Frame |
|---|---|---|
| Age as the predictor of higher ABT requirement | (years) | Retrospective analysis, 6-year period |
| Gender as the predictors of higher ABT requirement | male/female |
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Inclusion Criteria:
Exclusion Criteria:
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A retrospective cross-sectional study was conducted using an existing computerised medical records database at the Department of Anaesthesiology and Intensive Care at the Clinic for Cardiovascular Diseases Magdalena. This Clinic is a tertiary hospital in Croatia specialised in cardiac and vascular surgery. This study is a retrospective analysis of consecutive patients undergoing elective major vascular surgery who had been prospectively risk-stratified.
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20630687 | Background | Kent KC, Zwolak RM, Egorova NN, Riles TS, Manganaro A, Moskowitz AJ, Gelijns AC, Greco G. Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals. J Vasc Surg. 2010 Sep;52(3):539-48. doi: 10.1016/j.jvs.2010.05.090. Epub 2010 Jul 13. | |
| 20802228 | Background | Ashworth A, Klein AA. Cell salvage as part of a blood conservation strategy in anaesthesia. Br J Anaesth. 2010 Oct;105(4):401-16. doi: 10.1093/bja/aeq244. Epub 2010 Aug 28. |
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| Retrospective analysis, 6-year period |
| Body mass index (BMI) as the predictors of higher ABT requirement | BMI (kg/m2) | Retrospective analysis, 6-year period |
| Body surface area (BSA) as the predictors of higher ABT requirement | BSA (m²) | Retrospective analysis, 6-year period |
| Total blood volume as the possible predictors of higher ABT requirement | TBV (in liters) calculated trough Nadler's formula | Retrospective analysis, 6-year period |
| Hemoglobin (Hb) and hematocrit (Htc) as the predictors of higher ABT requirement | Hb (g/L) and Htc (%) | Retrospective analysis, 6-year period |
| Type of illness as the predictor of higher ABT requirement | abdominal aortic aneurysm or aortoiliac occlusive disease | Retrospective analysis, 6-year period |
| Patient's comorbidities as the predictors of higher ABT requirement | arterial hypertension, coronary artery disease, diabetes, atrial fibrillation, cerebrovascular incidents, chronic obstructive pulmonary disease, chronic renal insufficiency, malignancy | Retrospective analysis, 6-year period |
| Medications that impair coagulation and homeostasis as the predictor of higher ABT requirement | acetylsalicylic acid, clopidogrel, or warfarin | Retrospective analysis, 6-year period |
| Postoperative duration of mechanical ventilation | (hours) | Retrospective analysis, 6-year period |
| Length of stay (LOS) | LOS in ICU (days) and overall hospital LOS (days) | Retrospective analysis, 6-year period |
| In-hospital mortality rate | (in %) | Retrospective analysis, 6-year period |
| 24884605 | Background | Roubinian NH, Murphy EL, Swain BE, Gardner MN, Liu V, Escobar GJ; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III); Northern California Kaiser Permanente DOR Systems Research Initiative. Predicting red blood cell transfusion in hospitalized patients: role of hemoglobin level, comorbidities, and illness severity. BMC Health Serv Res. 2014 May 10;14:213. doi: 10.1186/1472-6963-14-213. |
| 19111480 | Background | Bursi F, Barbieri A, Politi L, Di Girolamo A, Malagoli A, Grimaldi T, Rumolo A, Busani S, Girardis M, Jaffe AS, Modena MG. Perioperative red blood cell transfusion and outcome in stable patients after elective major vascular surgery. Eur J Vasc Endovasc Surg. 2009 Mar;37(3):311-8. doi: 10.1016/j.ejvs.2008.12.002. Epub 2008 Dec 25. |