Comparison of Two Different Doses of Vitamin D in Preterm Infants

A Randomized Controlled Trial Comparing Two Regimens of Vitamin D Supplementation in Preterm Neonates

randomized clinical trial comparing two different doses of vitamin d supplementation in preterm infants

after randomization each group of preterm neonates (28-32) weeks consisting of 40 neonates

within 48 hrs of birth baseline ca.phosphorus, alkaline phosphatase and vitamin D level were withdrawn from each neonate

then babies started to take oral vitamin d in different doses (400 IU /day in the 1st group and 1000 iu per day in the 2nd group) after they reach 100 cc per kg per day enteral feeding

after they complete 40th week gestational age the investigators repeat the labs again ( serum ca, phosphorus,alp and vitamin D and compare the rate of rise in vitamin D and calcium

Inclusion Criteria:

• Preterm infants delivered at a gestational age ≤ 32 weeks
• Birth weight ≤1500 kg

Exclusion Criteria:

• Neonates with major congenital anomalies,
• maternal condition or medications likely to influence vitamin D or calcium metabolism
• neonates not receiving 100 ml/ kg / day of enteral feeds by 14 days of life