Reducing Concurrent Opioid-Benzodiazepine Prescriptions | NCT03887247 | Trialant

Reducing Concurrent Opioid-Benzodiazepine Prescriptions | NCT03887247 | Trialant

Sponsor/Collaborators Module

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
E-Mail Alert	Active Comparator	Send email to the patient's opioid prescriber(s), benzodiazepine prescriber(s), and/or primary care manager.	Behavioral: E-mail Alert
As-Usual	No Intervention	As-usual (no email) approach.

Interventions

Name	Type	Description	Arm Group Labels	Other Names
E-mail Alert	Behavioral	Encrypted email to the following providers: the patient's opioid prescriber(s), benzodiazepine prescriber(s), and/or primary care manager. If there is more than one provider, they are copied together on the same message. The email identifies the concurrent prescriptions, details the patient's prescription history, includes relevant VA/DoD guidelines, states the risk of concurrent prescribing to patient, and provides action steps and relevant resources. When multiple providers are involved, the message encourages the providers to coordinate with each other and provides provider contact information to facilitate this communication.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Overlapping Days	Overlapping days of opioids and benzodiazepines, determined using the dates of service and days supply of the prescription drug fills	90 days
Opioid Days	Days of opioids received	90 days
Benzodiazepine Days	Days of benzodiazepines received	90 days

Contacts/Locations Module

Overall Officials

Name	Affiliation	Role
Robert E Brutcher, PharmD,PhD	Walter Reed National Military Medical Center and Uniformed Services University of the Health Sciences	Principal Investigator
Alan Sim, PhD	Defense Health Agency	Principal Investigator
Elana Safran, MPP	General Services Administration (GSA)	Principal Investigator
Adam Sacarny, PhD	General Services Administration and Columbia University	Principal Investigator
Mary Steffel, PhD	General Services Administration and Northeastern University	Principal Investigator
Christopher J Spevak, MD, MPH, JD	Walter Reed National Medical Medical Center	Principal Investigator

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
36218952	Derived	Sacarny A, Safran E, Steffel M, Dunham JR, Abili OD, Mohajeri L, Oh PT, Sim A, Brutcher RE, Spevak C. Effect of Pharmacist Email Alerts on Concurrent Prescribing of Opioids and Benzodiazepines by Prescribers and Primary Care Managers: A Randomized Clinical Trial. JAMA Health Forum. 2022 Sep 2;3(9):e223378. doi: 10.1001/jamahealthforum.2022.3378.