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Comparative split face study in which 30 patients with freckles are recruited.One side of the face will be treated with Q Switched (QS)KTP 532nm, and the other side will be treated with intradermal tranexamic acid (TXA).
One side of the face will receive QS KTPlaser at a wavelength of 532 nm, spot size 2-3 mm , power 1-1.5J/cm2 and the clinical end point is just frosting.Sessions will be every month for 2 months.
The other side of the face will be assigned to TXA intradermal microinjection in the same session using Kapron 500mg/5ml ampoules (Amoun Pharmaceutical Company), the dose of 1 ml syringe with 100mg/ml. TXA will prepared under sterile conditions. Injections will be applied intradermally on freckles area at.
The sessions of TXA will be every 2 weeks for 2 months.
Postoperatively, topical antibiotic ointment and steriod will be applied. Sunscreen then applied until the next treatment in order to minimize reactive hyperpigmentations.
Follow up after treatment monthly for 2 month.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants with freckles (one side of the face) | Active Comparator | one randomized side of the face will be treated by Intradermal Tranexamic acid |
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| Participants with freckles (other side of the face) | Active Comparator | other side will be treated by Q switched KTP laser |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tranexamic Acid Injectable Product | Drug | Ampoules used for intradermal injection |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pigmentation and severity index by clinical evaluation | Evaluate efficacy of intradermal tranexamic acid versus Q switched KTP laser in the treatment of freckles before treatment, after treatment and after follow-up | 6 months to 1 year |
| Melanin Index change by spectrophotometer | Evaluate efficacy of intradermal tranexamic acid versus Q switched KTP laser in the treatment of freckles before treatment, after treatment and after follow-up | 6 months to 1 year |
| Blinded observers' evaluation | Evaluate efficacy of intradermal tranexamic acid versus Q switched KTP laser in the treatment of freckles before treatment, after treatment and after follow-up | 6 months to 1 year |
| Patient satisfaction rate | Evaluate efficacy of intradermal tranexamic acid versus Q switched KTP laser in the treatment of freckles before treatment, after treatment and after follow-up | 6 months to 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Samar Tuqan | Contact | 01003133495 | 02 | samartuqan@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kasr El Ainy university hospital | Recruiting | Cairo | 11956 | Egypt |
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| Q switched KTP (532nm) | Device | LASER |
|