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| Name | Class |
|---|---|
| University Hospital, Brest | OTHER |
| Rennes University Hospital | OTHER |
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Phenotypic characterisation of MVP by echocardiography in families. Identification of genes involved in MVP.
After clinical identification of patients with MVP, doctors organize 1st degree relative familial screening. A comprehensive echocardiography was carried out along with clinical examination. All echo data were stored for off-line analysis by a sonographer in our Core-lab. Blood was sample at the time of echocardiography in adult patients for DNA analyses. Follow-up for mitral valve changes will be performed after 5 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with MVP | The patients concerned are patients with known or recently discovered Barlow-type mitral prolapse, whatever the degree of severity. | ||
| Normal relatives | Related healthy patients, for an average of 6 individuals per family |
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| Measure | Description | Time Frame |
|---|---|---|
| MVP defined by a superior displacement of at least 2 mm | MVP defined by a superior displacement of at least 2 mm | At Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Comprehensive mitral valve apparatus characterization per size of items (leaflets, chordae, annulus) | Leaflets length ; Chordae length ; Annulus diameter | At Day 0 |
| Comprehensive mitral valve apparatus characterization per other items (papillary muscle, ventricles) |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of cardiac or clinical defects associated with MVP | Atrial septal defect, ventricular septal defect, patent ductus arteriosus, tricuspid or aortic valve abnormalities (prolapse, bicuspid AV…), coarctation, ascending aorta aneurysm | At Day 0 Follow-up will be carried out at 5 and 10 years |
Inclusion Criteria:
Exclusion Criteria:
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Patients of both sex of any age with typical mitral valve prolapse and relatives examined during familial screening
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Thierry Le Tourneau, PU-PH | Contact | 0617908670 | thletourneau@yahoo.fr |
| Name | Affiliation | Role |
|---|---|---|
| Vincent Probst, PU-PH | Nantes University Hospital | Principal Investigator |
| Hervé Le Marec, PU-PH | Nantes University Hospital | Principal Investigator |
| Jean-Jacques Schott, DR |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brest University Hospital | Not yet recruiting | Brest | 29200 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37204382 | Derived | Huttin O, Girerd N, Jobbe-Duval A, Constant Dit Beaufils AL, Senage T, Filippetti L, Cueff C, Duarte K, Fraix A, Piriou N, Mandry D, Pace N, Le Scouarnec S, Capoulade R, Echivard M, Sellal JM, Marrec M, Beaumont M, Hossu G, Trochu JN, Sadoul N, Marie PY, Guenancia C, Schott JJ, Roussel JC, Serfaty JM, Selton-Suty C, Le Tourneau T. Machine Learning-Based Phenogrouping in MVP Identifies Profiles Associated With Myocardial Fibrosis and Cardiovascular Events. JACC Cardiovasc Imaging. 2023 Oct;16(10):1271-1284. doi: 10.1016/j.jcmg.2023.03.009. Epub 2023 May 17. |
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| ID | Term |
|---|---|
| D008945 | Mitral Valve Prolapse |
| D030342 | Genetic Diseases, Inborn |
| ID | Term |
|---|---|
| D016127 | Heart Valve Prolapse |
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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whole blood
Papillary muscles aspect ; Right Ventricle function ; Left Ventricle Ejection Fraction |
| At Day 0 |
| Comprehensive mitral valve apparatus characterization per size of items (ventricle and atrium sizes) | Left ventricle and atrium sizes ; right ventricle size ; right Atrium size | At Day 0 |
| Comprehensive mitral valve apparatus characterization per size of items | Leaflets thickness | At Day 0 |
| Institut National de la Santé Et de la Recherche Médicale, France |
| Principal Investigator |
| Nantes University Hospital | Recruiting | Nantes | 44093 | France |
|
| Rennes University Hospital | Recruiting | Rennes | 35033 | France |
|
| D009358 |
| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |