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The main interest of this study is to investigate the influence of moderate alcohol consumption (beer) on salt-water homeostasis. Therefore, 10 healthy volunteers will participate in 4 Intervention:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Beer alone | Experimental | Consumption of beer (correlated for weight to reach a blood alcohol concentration of 0.8) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours. |
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| Beer and water | Active Comparator | Consumption of beer and additional water (correlated for weight to reach a blood alcohol concentration of 0.8, 1/3 of water, 2/3 of beer) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours. |
|
| Beer and stock | Active Comparator | Consumption of beer and additional stock(correlated for weight to reach a blood alcohol concentration of 0.8, 1/3 of stock, 2/3 of beer) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours. |
|
| Water alone | Placebo Comparator | Consumption of water alone (correlated for weight to reach a blood alcohol concentration of 0.8, 1/3 of stock, 2/3 of beer) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beer 5%o | Other | Weight adjusted beer to reach 0.8 blood alcohol content will be given over the time course of 1 hour to the participants |
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| Measure | Description | Time Frame |
|---|---|---|
| Difference in copeptin levels between the interventions | Difference in copeptin levels (pmol/l) between moderate beer consumption and moderate beer consumption with additional water and sodium (stock/bouillon) intake at timepoint 1.5 hours. | 30 minutes after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change in copeptin levels between the interventions throughout the observation period of 12 hours | Change in copeptin Levels (pmol/l) from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the Intervention, comparing the interventions | Observation period of 12 hours |
| Change in plasma sodium levels between the interventions throughout the observation period of 12 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mirjam Christ-Crain, Prof. Dr. MD | University Hospital, Basel, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Basel | Basel | 4031 | Switzerland |
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| ID | Term |
|---|---|
| D000428 | Alcohol Drinking |
| D003919 | Diabetes Insipidus |
| ID | Term |
|---|---|
| D004327 | Drinking Behavior |
| D001519 | Behavior |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
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| ID | Term |
|---|---|
| D014867 | Water |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 |
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| Beer 8.5%o and water | Other | Weight adjusted beer to reach 0.8 blood alcohol content and water will be given over the time course of 1 hour to the participants |
|
| Beer 8.5%o and stock | Other | Weight adjusted beer to reach 0.8 blood alcohol content and stock will be given over the time course of 1 hour to the participants |
|
| Water | Other | Water equivalent to the calculated volume of beer will be given over the time course of 1 hour to the participants |
|
Change in plasma sodium (mmol/l) from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions |
| Observation period of 12 hours |
| Change in urinary sodium levels between the interventions throughout the observation period of 12 hours | Change in urinary sodium (mmol/kg) from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions | Observation period of 12 hours |
| Change in plasma osmolality levels between the interventions throughout the observation period of 12 hours | Change in plasma osmolality (mmol/kg) levels from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions | Observation period of 12 hours |
| Change in urinary osmolality levels between the interventions throughout the observation period of 12 hours | Change in urinary osmolality (mmol/kg) levels from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions | Observation period of 12 hours |
| Change in plasma Glucose levels between the interventions throughout the observation period of 12 hours | Change in plasma glucose (mmol/l) levels from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions | Observation period of 12 hours |
| Change in biomarkers involved in the sodium-water homeostasis between the interventions throughout the observation period of 12 hours | Change in different biomarkers (e.g., Fibroblast growth factor 21, aldosterone, renin, Interleukin 6, Interleukin 8) from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions | Observation period of 12 hours |
| Difference in urinary excretion between the interventions throughout the observation period of 12 hours | Amount of total urinary excretion (ml) at time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours and 12 hours after start of the intervention, comparing the interventions | Observation period of 12 hours |
| Change in blood alcohol content between the interventions throughout the observation period of 12 hours | Change in blood alcohol content (°/oo) from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours and 12 hours after start of the intervention, comparing the interventions | Observation period of 12 hours |
| Difference in Response to lottery Experiment before and after the intervention | Change in decision making before and after the intervention, comparing the interventions | Directly before and 30 minutes after intervention |
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D010900 | Pituitary Diseases |
| D004700 | Endocrine System Diseases |
| Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |