Systemic Prevention and Management for Perioperative Hypothermia and Its Effect on Patients Outcome

Establishment of Systemic Prevention and Management for Perioperative Hypothermia and Its Effect on Patients Outcome-a Prospective Multiple Centers Randomized Controlled Study

This is a randomized, single-blinded, multi-center study clinical trial to determine both clinical and health outcomes of stratified warm strategy to prevent intraoperative hypothermia. Participants enrolled into this trial will be from elective major surgery population in PUMC Hospital, Beijing Hospital and Xuanwu Hospital. investigators plan to enroll approximately 800 participants. Hypothermia risk will be evaluated through PREDICTOR model in all participants. According to hypothermia risk level, these participants will be stratefied into high, moderate and low risk group. Participants in each group will be randomly categorize into warm group and control group. Active warm and fluid warm strategy, prewarm and fluid warm strategy and only prewarm strategy are used for high risk, moderate risk and low risk patients seperately. For controll group traditional passive warm was used.

Inclusion Criteria:

Age≥18 Core temperature preoperation ≥36.0 ℃ and ≤37.5℃ ASA I-III Informed consent

Exclusion Criteria:

• emergency operation
• uncontrolled diebete mellitus with insulin treatment （preoperative blood glucose>250mg/dL）
• hyperthyroidism and hypothyroidism
• Raynaud's disease
• patients with hematopathy and immune disease
• anticoagulant and non-steroid anti-inflammatory drug intake with 14 days before operation
• infectious fever within 4 weeks before operation
• laboratory abnomality as follow
• Hemoglobin≤10.0g/L
• Platelet≤100,000/ml
• White blood cell<3000/dl or>14,000/dl
• Fibrinogen<200mg/dL
• Thrombin time>40 second
• International normalized ratio<70%