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| Name | Class |
|---|---|
| Amarex Clinical Research | OTHER |
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The patient's local archival tumor tissue (FFPE) from original tumor, or from the metastatic tissue, will be collected to potentially identify if they - at a later stage of their disease - will be likely to benefit from treatment with any of the investigational cancer drugs available to Allarity Therapeutics. Data from this study can further be used to explore in a retrospective fashion, sensitivity to other chemotherapeutic drugs previously used in the treatment of their ovarian cancer, to investigate whether or not the DRP® method can predict and confirm the obtained sensitivity to the prior given drugs as well as prospective analyses guiding the Investigators on future treatments.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ovarian cancer patients | with formalin-fixed paraffin-embedded (FFPE) tumor tissue available |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Drug Response Predictor® (DRP) | Device | A DRP is an assay that based on samples from a tumor can predict whether the tumor will respond to a specific drug or not. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Identification of ovarian cancer patients with high likelihood of being sensitive to investigational cancer drug | based on FFPE ovarian cancer tissue | up to 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Retrospective analysis of whether or not the DRP method can predict and confirm the obtained sensitivity to the prior drugs used in the treatment of ovarian cancer | up to 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients will be identified at their already planned treatment and or at control visits at the oncology department
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| US: Kathleen Moore | Contact | +1 405-271-8707 | KathleenMoore@ouhealth.com | |
| Europe: Rebecca Kristeleit | Contact | Rebecca.Kristeleit@gstt.nhs.uk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dana-Farber Cancer Institute | Completed | Boston | Massachusetts | 02215 | United States | |
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| ID | Term |
|---|---|
| D010051 | Ovarian Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
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Samples with archival ovarian cancer tumor tissue is collected for measurement using mRNA or microRNA.
| OU Health Stephenson Cancer Center |
| Recruiting |
| Oklahoma City |
| Oklahoma |
| 73104 |
| United States |
|
| Swedish Center for Research and Innovation | Recruiting | Seattle | Washington | 98122 | United States |
|
| Beatson West of Scotland Cancer Centre | Active, not recruiting | Glasgow | Scotland | G12 0YN | United Kingdom |
| Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital | Active, not recruiting | London | United Kingdom |
| D000291 |
| Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D000091662 | Genital Diseases |
| D004700 | Endocrine System Diseases |
| D006058 | Gonadal Disorders |