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Investigators aim to evaluate the influence of cleft surgery on the tissue microcirculation of the palate with a non-invasive measurement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | cleft lip surgery only | ||
| medial incision only | Minimal incision group: palatoplasty using medial-only incisions | ||
| lateral incision | Lateral incision group: palatoplasty with lateral releasing incisions |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in tissue perfusion (regional tissue oxygen saturation (StO2%)) before and after surgery non-invasively measured | The difference and impact of our routine surgical technique on the tissue perfusion of the palate is measured non-invasively with a probe (regional StO2%). Localized measurement of the microvascular hemoglobin oxygen saturation. | One measurement before surgery, one measurement immediately after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Status of wound healing | status of wound healing, fistula formation | at 3 month and 6 month after surgery |
| Perioperative Complications |
|
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Inclusion Criteria:
Exclusion Criteria:
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Patients with orofacial clefts undergoing surgical repair of the deformity.
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| Name | Affiliation | Role |
|---|---|---|
| Benito K Benitez, MD DDS MHBA | University Basel and University Hospital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitätsspital Basel | Basel | Basel | 4310 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9727428 | Background | Huang MH, Lee ST, Rajendran K. Clinical implications of the velopharyngeal blood supply: a fresh cadaveric study. Plast Reconstr Surg. 1998 Sep;102(3):655-67. doi: 10.1097/00006534-199809030-00007. | |
| 23096613 | Background | Mueller AA, Schumann D, Reddy RR, Schwenzer-Zimmerer K, Mueller-Gerbl M, Zeilhofer HF, Sailer HF, Reddy SG. Intraoperative vascular anatomy, arterial blood flow velocity, and microcirculation in unilateral and bilateral cleft lip repair. Plast Reconstr Surg. 2012 Nov;130(5):1120-1130. doi: 10.1097/PRS.0b013e318267d4fb. |
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| ID | Term |
|---|---|
| D002972 | Cleft Palate |
| D002971 | Cleft Lip |
| ID | Term |
|---|---|
| D007569 | Jaw Abnormalities |
| D007571 | Jaw Diseases |
| D009140 | Musculoskeletal Diseases |
| D019767 | Maxillofacial Abnormalities |
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| 6 months |
| 28027255 | Background | Woo AS. Evidence-Based Medicine: Cleft Palate. Plast Reconstr Surg. 2017 Jan;139(1):191e-203e. doi: 10.1097/PRS.0000000000002854. |
| D019465 |
| Craniofacial Abnormalities |
| D009139 | Musculoskeletal Abnormalities |
| D009057 | Stomatognathic Diseases |
| D009056 | Mouth Abnormalities |
| D009059 | Mouth Diseases |
| D018640 | Stomatognathic System Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D008047 | Lip Diseases |