Forty male leukemic patients receiving chemotherapy were selected from National Cancer Institute, They were randomly assigned into two groups. Group (A) included 30 patients who were trained by Inspiratory muscle trainer for 4 weeks ;5 sessions/week and Group (B) included 10 patients as a control group.

The following measures were taken before and after the study period : Maximum voluntary ventilation(MVV) , 2 min walk test, FACT-G questionnaire

Forty male leukemic patients receiving chemotherapy for at least one cycle and their mean ages 37.1 ± 4.89 years.The patients were selected from National Cancer Institute, Cairo ( inpatient ward). The study lasted from March 2018 to June 2018. Patients were randomly assigned into two groups.Group A (30 patients) who received inspiratory muscles training for 4 successive weeks, 5 sessions/week; and Group B (10 patients) acted as a control group on chemotherapy only. Data obtained from both groups regarding (MVV), 2 min walk test and Quality of life questionnaire (FACT-G) were statistically analyzed and compared

Inclusion Criteria:

• male patient with age ranges from 30-50 years
• All patients were leukemic receiving chemotherapy for at least one cycle as a treatment of malignant tumor
• All patients were hemodynamically stable
• All patients were ambulant

Exclusion Criteria:

• lung cancer
• History of any pulmonary disease.
• Metastasis of lungs, ribs, mediastinal structure
• Pulmonary pathology(e.g acute respiratory distress syndrome or exacerbation of chronic obstructive pulmonary disease)
• ruptured ear drum or any other condition of the ear
• High peak airway pressure (barotraumas)
• patients with marked elevated left ventricular end diastolic volume and pressure
• patients with worsening heart failure signs and symptoms