Efficacy of Twice Weekly Hemodialysis in Patients With Residual Kidney Function

Efficacy of Twice Weekly Hemodialysis in Patients With Residual Kidney Function

The study will determine the efficacy of twice weekly hemodialysis in patients with residual kidney function.

Hemodialysis patients who have residual kidney function will undergo two 4-week study (twice weekly versus thrice weekly hemodialysis) using a cross-over design. Blood, urine, and dialysate samples will be collected at the end of each study period to determine adequacy of treatment and to assess uremic solute levels. Participants will complete quality of life questionnaires and cognitive paper tests.

Inclusion Criteria:

• patients on hemodialysis who have residual kidney function with residual urea clearance (Kru) >2.5 mL/min.
• been on hemodialysis for at least 3 months.
• adherence to regular dialysis treatments.

Exclusion Criteria:

• inability to achieve adequate hemodialysis.
• planned revision of hemodialysis vascular access.
• hospitalized within the past 2 months.