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The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation continuous renal replacement therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group | Multi-organ failure with acute kidney injury critically ill patients admitted to the intensive care unit undergoing regional citrate anticoagulation continuous renal replacement therapy by means of continuous veno-venous hemodiafiltration (CVVHDF). Multi-organ failure is defined as a respiratory, circulatory and renal failure. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| parathyroid hormone | Diagnostic Test | 10-20ml blood samples taken from the arterial catheter every 12 hours to obtain parathyroid hormone serum concentration. 6-8 samples per patient |
| Measure | Description | Time Frame |
|---|---|---|
| The change in parathyroid hormone serum concentration during regional citrate anticoagulation continuous renal replacement therapy (CRRT) in the acute phase of critical illness. | The first parathyroid hormone serum level will be measured before the start of CRRT (the zero point) Next measurements will be performed every 12 hours. Minimal number of measurements - 6, maximal - 8 per patient. | 96 hours |
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Inclusion Criteria:
Exclusion Criteria:
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Multi-organ failure with acute kidney injury critically ill patients admitted to the critical care unit undergoing regional citrate anticoagulation continuous renal replacement therapy by means of continuous veno-venous hemodiafiltration (CVVHDF). Multi-organ failure is defined as a respiratory, circulatory and renal failure.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Poland. | Wroclaw | Lower Silesian Voivodeship | 50-367 | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34010434 | Result | Czarnik A, Gawda R, Piwoda M, Marszalski M, Molsa M, Pietka M, Bolanowski M, Czarnik T. Parathyroid hormone serum concentration kinetic profile in critically ill patients undergoing continuous renal replacement therapies: a prospective observational study. Endokrynol Pol. 2021;72(4):329-335. doi: 10.5603/EP.a2021.0034. Epub 2021 May 19. |
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| ID | Term |
|---|---|
| D016638 | Critical Illness |
| D009102 | Multiple Organ Failure |
| D051437 | Renal Insufficiency |
| D012769 | Shock |
| D012131 | Respiratory Insufficiency |
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007674 | Kidney Diseases |
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blood samples (10-20ml) taken from the arterial catheter every 12 hours
| Department of Endocrinology, Szpital Wojewodzki w Opolu | Opole | Silesian Voivodeship | 45-372 | Poland |
| Department of Anesthesiology and Intensive Care, Uniwersytecki Szpital Kliniczny w Opolu | Opole | Silesian Voivodeship | 45-401 | Poland |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |