Parathyroid Hormone Kinetics During CRRT

Trends in Parathyroid Hormone Plasma Concentration in Multi-organ Failure Critically Ill Patients Undergoing Regional Citrate Anticoagulation Continuous Renal Replacement Therapies - Prospective Observational Study.

The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation continuous renal replacement therapy.

Inclusion Criteria:

• Acute respiratory failure
• Acute circulatory failure
• acute kidney injury treated with regional citrate anticoagulation continuous renal replacement therapy by means of continuous veno-venous hemodiafiltration (CVVHDF
• continuous renal replacement therapy started no later than 48 hours after admission
• SOFA score 5 or more

Exclusion Criteria:

• age less than 18 years
• acute liver failure
• hypercalcemia at admission (total calcium plasma level > 10.6 mg/dL; total ionized calcium plasma level > 1.35 mmol/L
• parathyroid glands disease
• end stage renal disease
• therapeutic plasma exchange
• extracorporeal membrane oxygenation
• unfavorable outcome (death) predicted within 72 hours (as assessed by investigator)
• lack of relatives consent