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This study aims to deep phenotype patients with rosacea and migraine
Rosacea and migraine are common disorders that overlap in epidemiology, symptoms, trigger factors, and distribution in the trigeminal area. Recent studies establish a connection between the two disorders, which needs to be investigated.
The purpose of this study is investigate the link between the two disorders by deep phenotyping through semi-structured interviews.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rosacea | Patients who have been diagnosed with rosacea |
| |
| Migraine | Patients who have been diagnosed with migraine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention apart from tests, including interview | Diagnostic Test | No interventions |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of migraine in rosacea cohort | Prevalence of patients in rosacea cohort who fulfill diagnostic criteria for migraine | 60 minutes |
| Prevalence of rosacea in migraine cohort Prevalence of rosacea in migraine cohort | Prevalence of patients in migraine cohort who fulfill diagnostic criteria for rosacea | 60 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of migraine subtypes in rosacea cohort | Prevalence of patients in rosacea cohort who fulfill diagnostic criteria for subtypes of migraine according to international headache society classification | 60 minutes |
| Prevalence of rosacea subtypes in migraine cohort |
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Inclusion Criteria:
Exclusion Criteria:
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Rosacea
Migraine
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| Name | Affiliation | Role |
|---|---|---|
| Messoud Ashina, MD, PhD, DMSc | Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Danish Headache Center | Glostrup | Region Sjælland | DK-2600 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38558478 | Derived | Wienholtz NKF, Christensen CE, Ashina H, Jorgensen NR, Egeberg A, Thyssen JP, Ashina M. Elevated plasma levels of calcitonin gene-related peptide in individuals with rosacea: A cross-sectional case-control study. J Eur Acad Dermatol Venereol. 2025 Jan;39(1):181-188. doi: 10.1111/jdv.19954. Epub 2024 Apr 1. | |
| 32819957 | Derived |
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| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| D012393 | Rosacea |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Mouthswab for DNA-sampling
Prevalence of patients in migraine cohort who fulfill diagnostic criteria for subtypes of rosacea |
| 60 minutes |
| Wienholtz NKF, Christensen CE, Haugaard JH, Zhang DG, Ashina M, Thyssen JP, Egeberg A. Cohort profile: COpenhagen ROsacea COhort (COROCO) and COpenhagen MIgraine COhort (COMICO). BMJ Open. 2020 Aug 20;10(8):e039445. doi: 10.1136/bmjopen-2020-039445. |
| D009422 | Nervous System Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |