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In the presented study, autonomic function as well as risk for atrial fibrillation will be assessed to characterize the relation between risk of atrial fibrillation and autonomic function.
Atrial fibrillation (AF) has been suggested as relevant comorbidity in patients with chronic obstructive pulmonary disease (COPD). The evaluation of the total atrial conduction time via tissue Doppler imaging (PA-TDI interval) can be used to identify patients with increased risk of new onset AF. Autonomic function can be assessed by different non invasive clinical investigations.
The investigators hypothesise that PA-TDI interval is increased in acutely exacerbated COPD (AECOPD) compared within stable COPD and that increased PA-TDI is related to impairment of autonomic function. For this purpose, 25 patients with AECOPD and 25 patients with stable COPD were characterized by clinical characteristics, laboratory tests, lung function, electrocardiography, echocardiography and autonomic function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AECOPD | acute exacerbation of COPD |
| |
| stable COPD |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Measurement of lung function, electrocardiography, echocardiography and autonomic function | Other | Measurement of lung function, electrocardiography, echocardiography and autonomic function |
| Measure | Description | Time Frame |
|---|---|---|
| total atrial conduction time | total atrial conduction time via tissue Doppler imaging (PA-TDI interval) | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate variability | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. | Baseline |
| Baroreflex sensitivity |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with chronic obstructive pulmonary disease, exacerbated or stable
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Düsseldorf, Division of Cardiology, Pulmonary Disease and Vascular Medicine | Düsseldorf | 40225 | Germany |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Collection of 20 ml of peripheral blood Clinical routine such as NTproBNP, renal function, thyroid function, blood count
For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
| Baseline |
| Chemoreflex sensitivity | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. | Baseline |
| Deep breathing test | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. | Baseline |
| Ewing test | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. | Baseline |
| Cold pressure test | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. | Baseline |
| Cold face test | For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive. | Baseline |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |