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this summary studied the predictive values of factor V Leiden mutation , doppler indices , placental pathology to unfavorable fetal and maternal outcomes
leiden mutation is activated protein C resistance with hypercoagulable states and increased thrombotic risk. 99 % are heterozygous and 1 % is homozygous , very rare cases are psoudohomozygous with factor V deficiency. relation to this mutation was studied in severe preeclamptic patients. doppler indices of uterine arteries , increased pulsetility index or unilateral or bilateral uterine artery notch and placental pathology were studied.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood sample , doppler of uterine vessel and placenta | Diagnostic Test | blood sample for factor V and doppler examination of uterine arteries , placenta pathology post partum |
| Measure | Description | Time Frame |
|---|---|---|
| percentage of patients develop abruption placenta, intrauterine growth retardation or delivered premature | placental abruption, prematurity, IUGR | within 12 wks from diagnosis of severe preeclampsia |
| percentage of fetuses and neonates complicated with intrauterine fetal death or need admission to incubator | IUFD, admission to neonatal IUC | from diagnosis of severe preeclampsia till one week after delivery |
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Inclusion Criteria: severe preeclampsia in 3rd trimester -
Exclusion Criteria:Twin pregnancy. Fetal congenital anomalies. Diabetic patient, impaired renal function. Any medical disorders even that HTN. Any placental pathology,Autoimmune diseases. Women with uterine activity or clinical emergencies with maternal hemodynamic instability or an indication for immediate termination of pregnancy.
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Pregnant women with preeclampsia in 3rd trimester. Singleton pregnancy. Accurate gestational age confirmed by last menstrual period or sonography before 20 weeks.
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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blood samples and placental pathology
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |