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The purpose of this study is to investigate the influence of baseline experimental pain sensitivity and expectation on the pain response following a single exercise session. Pain assessment will be done with different intensities of noxious stimuli. In addition, the expectation of how exercise impacts pain will be studied.
The relation between baseline pain sensitivity and the pain response following exercise is not clear. The aims of this study are to investigate the influence of baseline experimental pain sensitivity on the pain response following submaximal isometric exercise, and whether expectations would influence outcomes with subsequent exposure to exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| submaximal isometric exercise. | Experimental | submaximal isometric exercise will be performed. |
|
| Quiet rest. | No Intervention | Subject will rest in seating position for a period that mimics the exercise time. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Submaximal isometric exercise | Other | The exercise is a submaximal isometric contraction |
|
| Measure | Description | Time Frame |
|---|---|---|
| The change from baseline of pain ratings during temporal summation of pressure pain assessment | Temporal summation is the increase of pain over time caused by a constant or repetitive noxious stimulus. Pain reports will be obtained during the application of constant mechanical stimulus with various intensities. Subjects will be asked to rate the pain using a numerical pain rating scale that ranges from 0 (no pain) to 10 (worst pain). Pain ratings will be obtained at the beginning, during, and at the end of the test while a noxious stimulus is applied to the index finger. The change of pain ratings relative to baseline after exercise or quiet rest will be assessed. | Before and immediately after exercise or quiet rest in session 1 and session 2 which will be on day 1 and day 7 of data collection. |
| Measure | Description | Time Frame |
|---|---|---|
| Expectation | Subjects will be asked about their expectation of whether exercise will increase, decrease, or have no effect on the pain. | Before exercise which will be on day 1 and day 7 of data collection. |
| State version of the State-Trait Anxiety Inventory (STAI) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marie Hoeger Bement, PT, PhD | Contact | 414-288-6738 | mariehoeger.bement@marquette.edu |
| Name | Affiliation | Role |
|---|---|---|
| Marie Hoeger Bement, PT, PhD | Marquette University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Marquette University | Recruiting | Milwaukee | Wisconsin | 53201 | United States |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D010146 | Pain |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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All subjects will participate in two randomized sessions (an exercise session and control session). The exercise session consists of submaximal isometric exercise while the quiet rest session consists of a rest for a period that mimics the time spent in exercise.
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Participants are blinded to the hypothesis of this study.
A 20-item questionnaire from state-trait anxiety inventory that evaluates different feelings the subject may or may not have at the moment. The score of the questionnaire ranges from 0 to 80. Higher scores indicate greater state anxiety levels. |
| After each temporal summation protocol in the first and second session which are on day 1 and day 7 of data collection. |
| Trait version of the State-Trait Anxiety Inventory (STAI) | A 20-item questionnaire from state-trait anxiety inventory that evaluates how the subject feels in general and not restricted to the current moment. The score of the questionnaire ranges from 0 to 80. Higher scores indicate greater trait anxiety levels. | Baseline (beginning of session 1) which is day 1 of the data collection. |
| Pain catastrophizing scale | A 13-item scale that evaluates if the subject has an exaggerated negative mental set towards pain. It has 3 sub-scales which are magnification, rumination, and helplessness. The scores of the sub-scales are summed to get the total score. The total score ranges from 0 to 52. Greater scores indicate greater catastrophizing thinking. | Baseline (beginning of session 1) which is day 1 of the data collection. |
| Situational pain catastrophizing scale | A 6-item questionnaire that explores the negative mental set or catastrophizing thinking in reference to a particular experimental pain experience (i.e., temporal summation protocol). The score ranges from 0 to 24 with higher scores indicating greater situational catastrophizing. | After each temporal summation protocol in the first and second session which are day 1 and day 7 of data collection. |
| Physical activity assessment using International physical activity questionnaire. | International physical activity questionnaire (IPAQ) will be used to assess physical activity in the past week. IPAQ evaluates physical activity not only related to leisure time but also related to other domains such as transportation, work, gardening or house related physical activities. The questionnaire has been shown to be reliable and valid. The time spent in moderate to vigorous physical activity (minutes/ week) from every domain will be summed with 0 indicating no time (minutes / week) spent moderate to vigorous activities and higher values indicate greater time spent in moderate to vigorous physical activity. | Baseline (beginning of session 1 or 2) which is either day 1 or day 7 of data collection. |
| Muscle mass assessment using Dual-energy x-ray absorptiometry. | Dual-energy x-ray absorptiometry (General Electric Healthcare, Madison, Wisconsin) is an x-ray scan that is used to assess muscle mass. | Baseline (in the first or second session) which is either day 1 or day 7 of data collection. |
| Fat mass assessment using Dual-energy x-ray absorptiometry. | Dual-energy x-ray absorptiometry (General Electric Healthcare, Madison, Wisconsin) is an x-ray scan that is used to assess fat mass. | Baseline (in the first or second session) which is either day 1 or day 7 of data collection. |