Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants With Hepatocellular Carcinoma (HCC) and Complete... | NCT03867084 | Trialant

Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants With Hepatocellular Carcinoma (HCC) and Complete... | NCT03867084 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Has a diagnosis of HCC by radiological criteria and/or pathological confirmation.

Has an eligibility scan (CT of the chest, triphasic CT scan or MRI of the abdomen, and CT or MRI of the pelvis) confirming complete radiological response ≥4 weeks after complete surgical resection or local ablation. Randomization needs to occur within 12 weeks of the date of surgical resection or local ablation.

Has no radiologic evidence of disease prior to enrollment.

Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 within 7 days prior to Cycle 1, Day 1.

Has a Child-Pugh class A liver score (5 to 6 points) within 7 days prior to Cycle 1, Day 1.

Has alpha fetoprotein (AFP) concentration lower than 400 ng/mL within 28 days prior to Cycle 1, Day 1.

Has controlled hepatitis B (Hep B).

Has recovered adequately from toxicity and/or complications from the local intervention (surgical resection or local ablation) prior to starting study treatment.

If female, is not pregnant or breastfeeding, and at least one of the following conditions applies: 1) Is not a woman of childbearing potential (WOCBP); or 2) Is a WOCBP and using a contraceptive method that is highly effective or be abstinent from heterosexual intercourse as their preferred and usual lifestyle (a WOCBP must have a negative pregnancy test within 72 hours before the first dose of study treatment).

If undergoing surgical resection, has submitted a tumor tissue sample during Screening.

Has adequate organ function.

Exclusion Criteria:

Has a known additional malignancy that is progressing or has required active antineoplastic treatment (including hormonal) or surgery within the past 3 years.

Has had esophageal or gastric variceal bleeding within the last 6 months.

Has clinically apparent ascites on physical examination.

Has had clinically diagnosed hepatic encephalopathy in the last 6 months.

Has received local therapy to liver ablation other than with radiofrequency or microwave ablation.

Has a history of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease.

Has an active infection requiring systemic therapy.

Has dual active Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) infection at study entry.

Has a known history of human immunodeficiency virus (HIV) infection.

Has known active tuberculosis (TB; Bacillus tuberculosis).

Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (eg, CTLA-4, OX-40, CD137).

Has received prior systemic anti-cancer therapy for HCC including investigational agents.

Is receiving any of the following prohibited concomitant therapies:1) Antineoplastic systemic chemotherapy or biological therapy; 2) Immunotherapy not specified in this protocol; 3) Investigational agents other than pembrolizumab; 4) Radiation therapy; 5) Oncological surgical therapy; or systemic glucocorticoids for any purpose other than to modulate symptoms from an AE that is suspected to have an immunologic etiology.

Has received a live vaccine within 30 days prior to the first dose of study treatment.

Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to Cycle 1, Day 1.

Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to Cycle 1, Day 1.

Has severe hypersensitivity (≥Grade 3) to pembrolizumab and/or any of its excipients.

Has an active autoimmune disease that has required systemic treatment in past 2 years.

Has a known psychiatric or substance abuse disorder that would interfere with the participant's ability to cooperate with the requirements of the study.

Has had an allogenic tissue/solid organ transplant.

Banner MD Anderson Cancer Center ( Site 0026)

Gilbert, Arizona 85234, United States

The University of Arizona Cancer Center - North Campus ( Site 0039)

Tucson, Arizona 85719, United States

City of Hope Medical Center ( Site 0027)

Duarte, California 91010, United States

Smilow Cancer Hospital at Yale New Haven ( Site 0042)

New Haven, Connecticut 06510, United States

Regional Cancer Center ( Site 0054)

Fort Myers, Florida 33905, United States

Indiana University Simon Cancer Center ( Site 0075)

Indianapolis, Indiana 46202, United States

University of Iowa ( Site 0067)

Iowa City, Iowa 52242, United States

James Graham Brown Cancer Center ( Site 0088)

Louisville, Kentucky 40202, United States

University of Louisville ( Site 0059)

Louisville, Kentucky 40202, United States

University Medical Center New Orleans ( Site 0014)

New Orleans, Louisiana 70112, United States

Massachusetts General Hospital ( Site 0062)

Boston, Massachusetts 02114, United States

Boston Medical Center ( Site 0025)

Boston, Massachusetts 02118, United States

Beth Israel Deaconess Medical Ctr. ( Site 0033)

Boston, Massachusetts 02215, United States

University of Massachusetts Worcester ( Site 0017)

Worcester, Massachusetts 01655, United States

Henry Ford Hospital-GI/Hepatology Research ( Site 0047)

Detroit, Michigan 48202, United States

University of New Mexico ( Site 0041)

Albuquerque, New Mexico 87131, United States

North Shore-Long Island Jewish Health System ( Site 0068)

Lake Success, New York 11042, United States

Miami Valley Hospital South ( Site 0093)

Centerville, Ohio 45459, United States

University of Cincinnati Medical Center ( Site 0084)

Cincinnati, Ohio 45219, United States

ProMedica Flower Hospital ( Site 0090)

Sylvania, Ohio 43560, United States

Stephenson Cancer Center ( Site 0045)

Oklahoma City, Oklahoma 73104, United States

Vanderbilt Ingram Cancer Center ( Site 0006)

Nashville, Tennessee 37232, United States

Baylor Scott & White Medical Center - Temple ( Site 0089)

Temple, Texas 76508, United States

Virginia Mason Medical Center ( Site 0028)

Seattle, Washington 98101, United States

Hospital Universitario Austral ( Site 0795)

Pilar, Buenos Aires B1629AHJ, Argentina

Fundación favaloro para la Docencia e Investigación Médica ( Site 0808)

Buenos Aires, Buenos Aires F.D. C1096AAS, Argentina

Hospital Provincial del Centenario ( Site 0794)

Rosario, Santa Fe Province S2002KDS, Argentina

Hospital Aleman ( Site 0806)

Buenos Aires, C1118AAT, Argentina

Hospital Italiano ( Site 0793)

Buenos Aires, C1181ACH, Argentina

Hospital Britanico de Buenos Aires ( Site 0792)

Buenos Aires, C1280AEB, Argentina

Clinica de nefrologia urologia y enfermedades cardiovasculares ( Site 0802)

Santa Fe, S3000BPJ, Argentina

Royal Prince Alfred Hospital AW ( Site 0225)

Camperdown, New South Wales 2050, Australia

Liverpool Hospital ( Site 0226)

Liverpool, New South Wales 2170, Australia

Princess Alexandra Hospital ( Site 0228)

Woollongabba, Queensland 4102, Australia

Royal Adelaide Hospital ( Site 0234)

Adelaide, South Australia 5000, Australia

Monash Health ( Site 0233)

Clayton, Victoria 3168, Australia

St Vincents Hospital Melbourne ( Site 0227)

Fitzroy, Victoria 3065, Australia

Alfred Health ( Site 0230)

Melbourne, Victoria 3004, Australia

Royal Perth Hospital ( Site 0229)

Perth, Western Australia 6000, Australia

University Hospital Antwerp (UZA) ( Site 0374)

Edegem, Antwerpen 02650, Belgium

Erasme Hospital ( Site 0376)

Brussels, Bruxelles-Capitale, Region de 1070, Belgium

UZ Gent ( Site 0375)

Ghent, Oost-Vlaanderen 9000, Belgium

UZ Leuven ( Site 0377)

Leuven, Vlaams-Brabant 3000, Belgium

CIONC - Centro Integrado de Oncologia de Curitiba ( Site 0813)

Curitiba, Paraná 80810-050, Brazil

Hospital de Cancer de Pernambuco ( Site 0815)

Recife, Pernambuco 50040-000, Brazil

Hospital de Clinicas de Porto Alegre ( Site 0824)

Porto Alegre, Rio Grande do Sul 90035-903, Brazil

Clinica de Oncologia Reichow ( Site 0818)

Blumenau, Santa Catarina 89010-340, Brazil

Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 0820)

Itajaí, Santa Catarina 88301-220, Brazil

Hospital Paulistano ( Site 0829)

São Paulo, São Paulo 01321-001, Brazil

Instituto COI de Pesquisa Educacao e Gestao ( Site 0825)

Rio de Janeiro, 22793-080, Brazil

Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0826)

São Paulo, 01246-000, Brazil

Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 0828)

São Paulo, 01321-001, Brazil

A.C. Camargo Cancer Center ( Site 0827)

São Paulo, 01509-900, Brazil

Casa de Saude Santa Marcelina ( Site 0821)

São Paulo, 08270120, Brazil

Complex Cancer Center Plovdiv-First Medical Oncology Department ( Site 0982)

Plovdiv, 4004, Bulgaria

Nova Scotia Health Authority QEII-HSC ( Site 0208)

Halifax, Nova Scotia B3H 2Y9, Canada

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0211)

Montreal, Quebec H2X 3E4, Canada

McGill University Health Centre ( Site 0207)

Montreal, Quebec H4A 3J1, Canada

Anhui Provincil Hospital South District ( Site 0181)

Hefei, Anhui 230036, China

Cancer Hospital Chinese Academy of Medical Sciences ( Site 0156)

Beijing, Beijing Municipality 100021, China

Peking University People's Hospital ( Site 0191)

Beijing, Beijing Municipality 100044, China

Beijing Cancer Hospital ( Site 0155)

Beijing, Beijing Municipality 100142, China

Fujian Provincial Cancer Hospital ( Site 0165)

Fuzhou, Fujian 350014, China

900 Hospital of the Joint ( Site 0197)

Fuzhou, Fujian 350025, China

Guangdong General Hospital ( Site 0166)

Guangzhou, Guangdong 510080, China

Southern Medical University Nanfang Hospital ( Site 0172)

Guangzhou, Guangdong 510515, China

Wuhan Union Hospital ( Site 0173)

Wuhan, Hubei 430022, China

Hubei Cancer Hospital ( Site 0189)

Wuhan, Hubei 430079, China

The Third Xiangya Hospital of Central South University ( Site 0167)

Changsha, Hunan 410000, China

Hunan Provincial People Hospital ( Site 0192)

Changsha, Hunan 410005, China

Hunan Cancer Hospital ( Site 0168)

Changsha, Hunan 410013, China

Fudan University Shanghai Cancer Center ( Site 0161)

Shanghai, Shanghai Municipality 200032, China

Zhongshan Hospital Fudan University ( Site 0193)

Shanghai, Shanghai Municipality 200032, China

Renji Hospital Shanghai Jiaotong University School of Medicine ( Site 0174)

Shanghai, Shanghai Municipality 200127, China

Zhongshan Hospital affiliated to Fudan University ( Site 0153)

Shanghai, Shanghai Municipality 210000, China

The First Affiliated Hospital of Xi an Jiaotong University ( Site 0164)

Xi’an, Shanxi 710061, China

West China Hospital of Sichuan University ( Site 0162)

Chengdu, Sichuan 610041, China

Affiliated Tumor Hospital of Xinjiang Medical University ( Site 0157)

Ürümqi, Xinjiang 830001, China

Zhejiang Cancer Hospital ( Site 0171)

Hangzhou, Zhejiang 310022, China

Herlev Hospital ( Site 0421)

Herlev, Capital Region 2730, Denmark

Aarhus Universitets hospital ( Site 0420)

Aarhus N, Central Jutland 8200, Denmark

Odense Universitets Hospital ( Site 0422)

Odense C, Region Syddanmark 5000, Denmark

HUS Hopital Hautepierre ( Site 0445)

Strasbourg, Bas-Rhin 67098, France

Hopital de la Timone ( Site 0442)

Marseille, Bouches-du-Rhone 13005, France

CHU Bordeaux Haut-Leveque ( Site 0437)

Pessac, Gironde 33604, France

CHU Rangueil ( Site 0441)

Toulouse, Haute-Garonne 31059, France

Hopital Beaujon ( Site 0439)

Clichy, Hauts-de-Seine 92118, France

CHU Montpellier. ( Site 0443)

Montpellier, Herault 34295, France

Hopital Claude Huriez CHRU LILLE ( Site 0440)

Lille, Nord 59037, France

Hopital Paul Brousse ( Site 0447)

Villejuif, Val-de-Marne 94800, France

SLK-Kliniken Heilbronn GmbH ( Site 0460)

Heilbronn, Baden-Wurttemberg 74078, Germany

Universitaetsklinikum Tuebingen ( Site 0466)

Tübingen, Baden-Wurttemberg 72076, Germany

Klinikum rechts der Isar der Technischen Universitaet ( Site 0470)

Munich, Bavaria 81675, Germany

Universitaetsklinikum Wuerzburg ( Site 0468)

Würzburg, Bavaria 97080, Germany

Krankenhaus Nord-West GmbH ( Site 0472)

Frankfurt am Main, Hesse 60488, Germany

Universitaetsklinikum Frankfurt ( Site 0467)

Frankfurt am Main, Hesse 60596, Germany

Medizinische Hochschule Hannover ( Site 0458)

Hanover, Lower Saxony 30625, Germany

Universitaetsklinikum Koeln ( Site 0463)

Cologne, North Rhine-Westphalia 50937, Germany

Universitaetsklinikum Duesseldorf ( Site 0461)

Düsseldorf, North Rhine-Westphalia 40225, Germany

Staedtisches Klinikum Dresden ( Site 0471)

Dresden, Saxony 01067, Germany

Universitatsklinikum Carl Gustav Carus ( Site 0459)

Dresden, Saxony 01307, Germany

Charite - Campus Virchow Klinikum ( Site 0457)

Berlin, 13353, Germany

Universitaetsklinikum Hamburg-Eppendorf ( Site 0469)

Hamburg, 20246, Germany

Prince of Wales Hospital ( Site 0268)

Hong Kong, 000, Hong Kong

Pamela Youde Nethersole Eastern Hospital ( Site 0271)

Hong Kong, Hong Kong

Queen Mary Hospital ( Site 0267)

Hong Kong, Hong Kong

Tuen Mun Hospital ( Site 0272)

Tuenmen, Hong Kong

Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 0483)

Kecskemét, Bács-Kiskun county 6000, Hungary

SZTE Szent-Gyorgyi Albert Klinikai Kozpont ( Site 0482)

Szeged, Csongrád megye 6720, Hungary

Somogy Megyei Kaposi Mór Oktató Kórház-Oncology center ( Site 0484)

Kaposvár, Somogy County 7400, Hungary

Semmelweis University ( Site 0480)

Budapest, 1085, Hungary

Debreceni Egyetem Klinikai Kozpont Onkologiai Tanszek ( Site 0481)

Debrecen, 4032, Hungary

St Vincent's University Hospital ( Site 0498)

Dublin, D04 T6F4, Ireland

Tallaght University Hospital ( Site 0499)

Dublin, D24 NR0A, Ireland

Rambam Medical Center ( Site 0524)

Haifa, 3109601, Israel

Haddassah Medical Organization - Ein Kerem ( Site 0519)

Jerusalem, 9112001, Israel

Rabin Medical Center ( Site 0520)

Petah Tikva, 4941492, Israel

Chaim Sheba Medical Center ( Site 0523)

Ramat Gan, 5262000, Israel

Sourasky Medical Center ( Site 0522)

Tel Aviv, 6423906, Israel

A O U Policlinico di Modena ( Site 0548)

Modena, Abruzzo 41025, Italy

Azienda Ospedaliera Ordine Mauriziano di Torino ( Site 0542)

Turin, Piedmont, Italy

Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello ( Site 0547)

Palermo, Sicily 90146, Italy

Istituto Tumori Giovanni Paolo II ( Site 0543)

Bari, 70124, Italy

AOU di Bologna Policliico S. Orsola-Malpighi ( Site 0541)

Bologna, 40138, Italy

Azienda Ospedaliero Universitaria Careggi ( Site 0549)

Florence, 50134, Italy

Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico ( Site 0550)

Milan, 20122, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0540)

Milan, 20133, Italy

Ospedale del Mare ( Site 0545)

Naples, 80147, Italy

Azienda Ospedaliero Universitaria Pisana ( Site 0546)

Pisa, 56126, Italy

Ehime University Hospital ( Site 0123)

Tōon, Ehime 791-0295, Japan

Kurume University Hospital ( Site 0119)

Kurume, Fukuoka 830-0011, Japan

Hokkaido P.W.F.A.C Sapporo-Kosei General Hospital ( Site 0102)

Sapporo, Hokkaido 060-0033, Japan

Kanazawa University Hospital ( Site 0111)

Kanazawa, Ishikawa-ken 920-8641, Japan

Kagawa University Hospital ( Site 0121)

Kita-gun, Kagawa-ken 761-0793, Japan

Kagawa Prefectural Central Hospital ( Site 0122)

Takamatsu, Kagawa-ken 760-8557, Japan

Toranomon Hospital Kajigaya ( Site 0109)

Kawasaki, Kanagawa 213-8587, Japan

Yokohama City University Medical Center ( Site 0110)

Yokohama, Kanagawa 232-0024, Japan

Kindai University Hospital ( Site 0116)

Sayama, Osaka 5898511, Japan

Saitama Medical University Hospital ( Site 0104)

Iruma-gun, Saitama 350-0495, Japan

Kyorin University Hospital ( Site 0106)

Mitaka, Tokyo 181-8611, Japan

Musashino Red Cross Hospital ( Site 0107)

Musashino, Tokyo 180-8610, Japan

Chiba University Hospital ( Site 0103)

Chiba, 260-8677, Japan

National Hospital Organization Kyushu Medical Center ( Site 0118)

Fukuoka, 810-8563, Japan

Hiroshima University Hospital ( Site 0117)

Hiroshima, 7348551, Japan

University Hospital, Kyoto Prefectural University of Medicine ( Site 0112)

Kyoto, 602-8566, Japan

Japanese Red Cross Osaka Hospital ( Site 0113)

Osaka, 543-8555, Japan

Osaka Metropolitan University Hospital. ( Site 0114)

Osaka, 545-8586, Japan

Saga-Ken Medical Centre Koseikan ( Site 0120)

Saga, 840-8571, Japan

Toranomon Hospital ( Site 0108)

Tokyo, 105-8470, Japan

The University of Tokyo Hospital ( Site 0105)

Tokyo, 113-8655, Japan

Wakayama Medical University Hospital ( Site 0115)

Wakayama, 641-8510, Japan

Hospital Universiti Sains Malaysia ( Site 0295)

Kubang Kerian, Kelantan 16150, Malaysia

Gleneagles Penang ( Site 0290)

George Town, Pulau Pinang 10050, Malaysia

Penang Adventist Hospital ( Site 0289)

George Town, Pulau Pinang 10350, Malaysia

Institut Kanser Negara - National Cancer Institute ( Site 0294)

Putrajaya Wilayah Persekutuan, Putrajaya 62250, Malaysia

Sarawak General Hospital ( Site 0293)

Kuching, Sarawak 93586, Malaysia

University Malaya Medical Centre ( Site 0288)

Kuala Lumpur, 59100, Malaysia

Christchurch Hospital ( Site 0247)

Christchurch, Canterbury 8011, New Zealand

Auckland City Hospital ( Site 0246)

Auckland, 1142, New Zealand

Oslo Universitetssykehus HF. Ulleval ( Site 0433)

Oslo, 0450, Norway

Izerskie Centrum Pulmonologii i Chemioterapii IZER-MED Spolka z o.o. ( Site 0607)

Szklarska Poręba, Lower Silesian Voivodeship 58-580, Poland

Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie ( Site 0620)

Lublin, Lublin Voivodeship 20-081, Poland

MTZ Clinical Research Sp. z o. o. ( Site 0608)

Warsaw, Masovian Voivodeship 02-106, Poland

Copernicus PL Sp. z o.o. ( Site 0603)

Gdansk, Pomeranian Voivodeship 80-219, Poland

ID Clinic ( Site 0619)

Mysłowice, Silesian Voivodeship 41-400, Poland

SPZOZ MSWIA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie ( Site 0606)

Olsztyn, Warmian-Masurian Voivodeship 10-228, Poland

Szpital Wojewodzki im. Mikolaja Kopernika ( Site 0604)

Koszalin, West Pomeranian Voivodeship 75-581, Poland

Altay Regional Oncology Dispensary ( Site 0919)

Barnaul, Altayskiy Kray 656045, Russia

Siberian Clinical Center of FMBA ( Site 0918)

Krasnoyarsk, Krasnoyarsk Krai 660037, Russia

Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0648)

Krasnoyarsk, Krasnoyarsk Krai 660133, Russia

Blokhin National Medical Oncology ( Site 0645)

Moscow, Moscow 115478, Russia

City Clinical Hospital 1 na. NI. Pirogov ( Site 0662)

Moscow, Moscow 119049, Russia

First Moscow State Medical University n.a. I.M.Sechenov ( Site 0661)

Moscow, Moscow 119881, Russia

Hadassah Medical-Clinical Research Department ( Site 0920)

Moscow, Moscow 121205, Russia

National Medical Research Radiological Centre ( Site 0660)

Moscow, Moscow 125284, Russia

Privolzhsky District Medical Center ( Site 0655)

Nizhny Novgorod, Nizhny Novgorod Oblast 603109, Russia

Samara Regional Clinical Oncology Center ( Site 0656)

Samara, Samara Oblast 443031, Russia

Road Hospital JSC Russian railways ( Site 0649)

Saint Petersburg, Sankt-Peterburg 195271, Russia

Russian Scientific Center of Radiology and Surgical Technologies ( Site 0665)

Saint Petersburg, Sankt-Peterburg 197758, Russia

City Clinical Oncology Center ( Site 0646)

Saint Petersburg, Sankt-Peterburg 198255, Russia

Tomsk Scientific Research Institute of Oncology ( Site 0657)

Tomsk, Tomsk Oblast 634028, Russia

National Cancer Center ( Site 0314)

Goyang-si, Kyonggi-do 10408, South Korea

Seoul National University Bundang Hospital ( Site 0313)

Seongnam-si, Kyonggi-do 13605, South Korea

Seoul National University Hospital ( Site 0312)

Seoul, 03080, South Korea

Severance Hospital Yonsei University Health System ( Site 0309)

Seoul, 03722, South Korea

Asan Medical Center ( Site 0310)

Seoul, 05505, South Korea

Samsung Medical Center ( Site 0311)

Seoul, 06351, South Korea

The Catholic University of Korea. Seoul St. Mary s Hospital ( Site 0315)

Seoul, 06591, South Korea

Hospital Universitari Parc Tauli ( Site 0681)

Sabadell, Barcelona 08208, Spain

Hospital Universitario de Donostia ( Site 0671)

Donostia / San Sebastian, Gipuzkoa 20014, Spain

Complejo Hospitalario Universitario de Santiago ( Site 0668)

Santiago de Compostela, La Coruna 15706, Spain

Hospital Universitario Puerta de Hierro ( Site 0678)

Majadahonda, Madrid 28222, Spain

Hospital Central de Asturias ( Site 0667)

Oviedo, Principality of Asturias 33011, Spain

Hospital Universitari Vall d Hebron ( Site 0674)

Barcelona, 08035, Spain

Hospital General Universitario Gregorio Maranon ( Site 0676)

Madrid, 28007, Spain

Hospital Ramon y Cajal ( Site 0673)

Madrid, 28034, Spain

Hospital Universitario La Paz ( Site 0677)

Madrid, 28046, Spain

Hospital Universitario Virgen del Rocio ( Site 0670)

Seville, 41013, Spain

Hospital Universitario Miguel Servet-Gastroenterology ( Site 0682)

Zaragoza, 50009, Spain

Skane University Hospital ( Site 0692)

Malmö, Skåne County 205 02, Sweden

Karolinska Universitetssjukhuset, Huddinge ( Site 0689)

Stockholm, Stockholm County 141 86, Sweden

Norrlands Universitetssjukhus ( Site 0687)

Umeå, Västerbotten County 901 85, Sweden

Sahlgrenska Universitetssjukhuset ( Site 0691)

Gothenburg, Västra Götaland County 413 46, Sweden

Universitaetsspital Bern ( Site 0710)

Bern, Canton of Aargau 3010, Switzerland

University Hospital Basel ( Site 0709)

Basel, Canton of Basel-City 4056, Switzerland

Kantonsspital St. Gallen ( Site 0708)

Sankt Gallen, Canton of St. Gallen 9007, Switzerland

CHUV (centre hospitalier universitaire vaudois) ( Site 0712)

Lausanne, Canton of Vaud 1011, Switzerland

Kantonsspital Winterthur ( Site 0714)

Winterthur, Canton of Zurich 8401, Switzerland

Hopitaux Universitaires de Geneve HUG ( Site 0711)

Geneva, 1211, Switzerland

Universitaetsspital Zurich ( Site 0713)

Zurich, 8091, Switzerland

Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0335)

Kaohsiung City, 833, Taiwan

China Medical University Hospital ( Site 0333)

Taichung, 40447, Taiwan

National Cheng Kung University Hospital ( Site 0334)

Tainan, 704, Taiwan

National Taiwan University Hospital ( Site 0330)

Taipei, 100, Taiwan

Taipei Veterans General Hospital ( Site 0331)

Taipei, 112, Taiwan

Chang Gung Medical Foundation. Linkou ( Site 0332)

Taoyuan, 333, Taiwan

Ramathibodi Hospital. ( Site 0352)

Bangkok, Bangkok 10400, Thailand

Siriraj Hospital ( Site 0351)

Bangkok, Bangkok 10700, Thailand

Maharaj Nakorn Chiangmai Hospital ( Site 0353)

Chiang Mai, 50200, Thailand

Srinagarind Hospital ( Site 0354)

Khon Kaen, 40002, Thailand

Namik Kemal Universitesi Tip Fakultesi ( Site 0738)

Tekirdağ, Tekirdas 59100, Turkey (Türkiye)

Baskent Unv. Adana Uyg. ve Arast. Hastanesi ( Site 0733)

Adana, 01120, Turkey (Türkiye)

Gulhane Egitim ve Arastirma Hastanesi ( Site 0741)

Ankara, 06010, Turkey (Türkiye)

Ankara Sehir Hastanesi ( Site 0731)

Ankara, 06800, Turkey (Türkiye)

Adnan Menderes University Medical Faculty ( Site 0737)

Aydin, 09010, Turkey (Türkiye)

Bezmialem Vakif University School of Medicine ( Site 0732)

Istanbul, 34093, Turkey (Türkiye)

Acıbadem Maslak Hastanesi ( Site 0742)

Istanbul, 34457, Turkey (Türkiye)

Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0730)

Istanbul, 34722, Turkey (Türkiye)

Dokuz Eylul Universitesi ( Site 0740)

Izmir, 35340, Turkey (Türkiye)

Konya Necmettin Erbakan University Medical Faculty ( Site 0736)

Konya, 42080, Turkey (Türkiye)

Inonu University Faculty of Medicine ( Site 0729)

Malatya, 44280, Turkey (Türkiye)

VM Medical Park Hastanesi ( Site 0739)

Mersin, 33440, Turkey (Türkiye)

Regional Clinical Onco Dispensary_ State Medical University ( Site 0782)

Chernivtsi, Chernivetska Oblast 58000, Ukraine

Regional Oncology Center of Kharkiv ( Site 0777)

Kharkiv, Kharkiv Oblast 61000, Ukraine

National Cancer Institute of the MoH of Ukraine ( Site 0779)

Kyiv, Kyivska Oblast 03022, Ukraine

Shalimov s NI of Surgery and Transplantation ( Site 0781)

Kyiv, Kyivska Oblast 03126, Ukraine

MI Odessa Regional Oncological Centre ( Site 0776)

Odesa, Odesa Oblast 65055, Ukraine

CI City Clinical Hospital # 3 ( Site 0783)

Zaporizhzhya, Zaporizhzhia Oblast 69032, Ukraine

Universal Clinic Oberig-Oncology Center ( Site 0786)

Kyiv, 03057, Ukraine

Medical Center Dobrobut Clinic ( Site 0785)

Kyiv, 03151, Ukraine

Cambridge University Hospitals NHS Trust ( Site 0755)

Cambridge, Cambridgeshire CB2 0QQ, United Kingdom

Weston Park Hospital ( Site 0753)

Sheffield, Derbyshire S10 2SJ, United Kingdom

The Beatson West of Scotland Cancer Centre ( Site 0750)

Glasgow, Glasgow City G12 0YN, United Kingdom

Kings College Hospital NHS Foundation Trust ( Site 0758)

London, London, City of SE5 9RS, United Kingdom

Belfast City Hospital ( Site 0752)

Belfast, Northern Ireland BT9 7AB, United Kingdom

The Clatterbridge Cancer Centre NHS Foundation Trust ( Site 0757)

Birkenhead, Wirral CH63 4JY, United Kingdom

University Hospital Coventry and Warwickshire NHS Trust ( Site 0754)

Coventry, CV3 2DX, United Kingdom

Leeds Teaching Hospitals NHS Trust ( Site 0751)

Leeds, LS9 7TF, United Kingdom

Nottingham University Hospitals NHS Trust ( Site 0756)

Nottingham, NG5 1PB, United Kingdom