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Patients with traveller's diarrhoea frequently harbour Extended Spectrum Betalactamase (ESBL)-producing Enterobacteriaceae (EPE) returning from EPE-endemic areas.
This study investigates to what extent travellers returning to Sweden with traveller's diarrhoea carry ESBL in their stool. The isolates are examined further according to species, phenotype, antibiogram and whole genome sequencing.
Samples sent to the department of clinical microbiology in Lund, Sweden for culture of salmonella, shigella, yersinia or campylobacter are also cultured selectively for ESBL.
All patients are contacted by mail with the results. ESBL-positive patients are invited to submit further faecal cultures and blood samples during one year follow up time, to investigate how long the patient is colonized with ESBL.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ESBL carrier | This cohort is followed for a year with additional selective ESBL cultures after 1, 3, 6 and 12 months. In the end of the year a questionnaire is handed in to the study group. Sera is donated after 4-6 weeks and in year. |
| |
| Non ESBL-carrier | No further rectal cultures. In the end of the year a questionnaire is handed in to the study group. Sera is donated after 4-6 weeks and in year. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention, observational | Other | See above |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion ESBL-colonized after one year. | Defined as a Positive ESBL-culture obtained 12 months after travel | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Travellers of all ages
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| Name | Affiliation | Role |
|---|---|---|
| Oskar Ljungquist | Lunds Universitet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oskar Ljungquist | Helsingborg | Skåne County | 25187 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32988817 | Derived | Ljungquist O, Camporeale A, Nematzadeh S, Giske CG, Resman F, Riesbeck K, Tham J. A Cross-Sectional Cohort Study of Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Patients with Traveler's Diarrhea. Antimicrob Agents Chemother. 2020 Nov 17;64(12):e01585-20. doi: 10.1128/AAC.01585-20. Print 2020 Nov 17. |
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Rectal cultures and blood samples