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| Name | Class |
|---|---|
| Beijing Municipal Science & Technology Commission | OTHER |
| China-Japan Friendship Hospital | OTHER |
| Beijing Friendship Hospital | OTHER |
| Beijing Hospital |
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With the rapid increase of diabetic nephropathy worldwide, type 2 diabetes mellitus(DM) is the leading cause of end-stage renal disease(ESRD). Pathological types of diabetic kidney disease(DKD) could be mainly divided into diabetic nephropathy（DN）and non-diabetic renal diseases（NDRD）. There are no accurate renal biopsy indications and standardized operation procedures for type 2 diabetic nephropathy. The clinical stages of type 2 diabetic nephropathy still referred to the Mogensen stage of type 1 diabetic nephropathy. Thus, our study aim to clarify the differences in clinical phenotype between type 2 DN and type 2 NDRD, analysis the correlation between clinical and pathological features, and offer the criteria for clinical staging and prognosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 2 diabetic nephropathy | The cohort will be followed for at least 10 years. The cohort will be divided into 2 groups according the pathological results of patients,and at least 3 groups according to clinical features such as renal function and proteinuria. |
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| Measure | Description | Time Frame |
|---|---|---|
| change in eGFR and urine protein from baseline | eGFR is calculated using the CKD-EPI formula, involving gender, age, and serum creatinine. | 24months |
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Inclusion Criteria:
Exclusion Criteria:
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The aim of this study is to clarify the differences in clinical phenotype between type 2 DN and type 2 NDRD, analysis the correlation between clinical and pathological features, and offer the criteria for clinical staging and prognosis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiangmei Chen, MD.&Ph.D | Contact | +86 010 66935462 | xmchen301@126.com | |
| Zheyi Dong, MD.&Ph.D | Contact | +86 010 66935462 | shengdai26@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Xiangmei Chen, MD.&Ph.D | Chinese PLA General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chinese PLA General Hospital | Recruiting | Beijing | Beijing Municipality | 100853 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42008071 | Derived | Wang Q, Zhou S, Niu Y, Li C, Lyu Q, Chen P, Zhang X, Xie L, Shen W, Wang Y, Cao X, Cai G, Chen X, Wang H, Dong Z. Clinical utility of BOLD-MRI in accurate diagnosis and prognostic evaluation of diabetic nephropathy: a prospective renal biopsy-based cohort study. Insights Imaging. 2026 Apr 20;17(1):106. doi: 10.1186/s13244-026-02274-9. | |
| 39856403 |
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The test has not been completed.
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| ID | Term |
|---|---|
| D003928 | Diabetic Nephropathies |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| OTHER_GOV |
| Fourth Medical Center of PLA General Hospital | OTHER |
| The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | OTHER |
| Third Medical Center of Chinese PLA General Hospital | OTHER |
| Shanghai Jiao Tong University Affiliated Sixth People's Hospital | OTHER |
| The First Affiliated Hospital of Dalian Medical University | OTHER |
| Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | OTHER |
| First Teaching Hospital of Tianjin University of Traditional Chinese Medicine | OTHER |
| Guang'anmen Hospital of China Academy of Chinese Medical Sciences | OTHER |
| Dongzhimen Hospital, Beijing | OTHER |
| Shanghai University of Traditional Chinese Medicine | OTHER |
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Blood, urine, kidney tissue
| Dong Z, Wang X, Pan S, Weng T, Chen X, Jiang S, Li Y, Wang Z, Cao X, Wang Q, Chen P, Jiang L, Cai G, Zhang L, Wang Y, Yang J, He Y, Lin H, Wu J, Tang L, Zhou J, Li S, Li Z, Fu Y, Yu X, Geng Y, Zhang Y, Wang L, Xu M, Chen X. A multimodal transformer system for noninvasive diabetic nephropathy diagnosis via retinal imaging. NPJ Digit Med. 2025 Jan 24;8(1):50. doi: 10.1038/s41746-024-01393-1. |
| 38344659 | Derived | Wang Q, Cheng H, Jiang S, Zhang L, Liu X, Chen P, Liu J, Li Y, Liu X, Wang L, Li Z, Cai G, Chen X, Dong Z. The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes. Front Endocrinol (Lausanne). 2024 Jan 26;15:1292412. doi: 10.3389/fendo.2024.1292412. eCollection 2024. |
| 35846333 | Derived | Zhang W, Liu X, Dong Z, Wang Q, Pei Z, Chen Y, Zheng Y, Wang Y, Chen P, Feng Z, Sun X, Cai G, Chen X. New Diagnostic Model for the Differentiation of Diabetic Nephropathy From Non-Diabetic Nephropathy in Chinese Patients. Front Endocrinol (Lausanne). 2022 Jun 30;13:913021. doi: 10.3389/fendo.2022.913021. eCollection 2022. |
| 35679002 | Derived | Qu YL, Dong ZY, Cheng HM, Liu Q, Wang Q, Yang HT, Mao YH, Li JJ, Liu HF, Geng YQ, Huang W, Liu WH, Xie HD, Peng F, Li S, Jiang SS, Li WZ, Duan SW, Feng Z, Zhang WG, Liu YN, Tian JZ, Chen XM. Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated Chinese and Western Medicine. Chin J Integr Med. 2023 Apr;29(4):308-315. doi: 10.1007/s11655-022-3520-0. Epub 2022 Jun 9. |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D048909 | Diabetes Complications |
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |