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Psoriasis in a systemic disease that effects many systems of the body. few studies examined the hearing function of these patients but the results were inconclusive. No study, however, investigated the vestibular function of psoriatic patients.
In a prospective study, the investigators will compare audiovestibular function between psoriatic patients and healthy volunteers. .
Whether psoriatic patients have higher risk for developing inner ear dysfunction (hearing loss and dizziness) is an important issue that needs to be elucidated. Awareness to the elevated risk (if there is any) of inner ear impairment, early detection and treatment of the condition may reduce the morbidities resulting from undiagnosed audiovestibular impairment.
In a prospective study the investigators will examine the inner ear function (vestibular and auditory) of psoriatic patients and compare it to an healthy, young control group.
The study will include 2 groups of participants: psoriatic patients and healthy volunteers. psoriatic patients are recruited from the dermatology clinic while the healthy volunteers are members of the hospital staff.
The participants will undergo 2 sets of examinations:
auditory function examination: hearing test (that includes pure tone audiometry, speech audiometry and discrimination level), tympanometry and otoacoustic emissions.
vestibular function examination:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| psoriatic patients | Active Comparator | psoriatic patients that are recruited from the dermatology clinic. This arm will undergo audiovestibular evaluation. |
|
| healthy volunteers | Active Comparator | Healthy volunteers that are members of the hospital staff and will be recruited from the hospital. This arm will undergo audiovestibular evaluation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| audiovestibular function | Device | Hearing test- includes a pure tone audiometry, speech audiometry and discrimination level. tympanometry- Includes inserting headphones into the participants ears and computer calculation the compliance of the eardrum. otoacoustic emission: Includes headphones insertion and calculation of the inner ear audiological function. Video head impulse test. - Dizziness handicap inventory questionnaire. questionnaire filled by the participants provides a subjective data regarding the severity of the dizziness. |
| Measure | Description | Time Frame |
|---|---|---|
| Hearing test | Determining the threshold of each measured tone in decibel units. | up to 2 weeks after recruitment. estimation time of the outcome is 10 minutes. |
| Hearing test | Determining the speech threshold in decibel units. | up to 2 weeks after recruitment. estimation time of the outcome is 10 minutes. |
| Tympanometry | Determining the type of tympanometry ( one out of the 3 possible options:A,B,C) | up to 2 weeks after recruitment. estimation time of the outcome is 3 minutes. |
| Otoacoustic emission | Determining existence or abscence of physiologic otoacoustic emissions in 500, 1000, 2000 Herts. | up to 2 weeks after recruitment. estimation time of the outcome is 3 minutes. |
| Video head impulse test | Measuring the velocity of eye movement compared to velocity of the head while the head is thrusted. The measured units are degrees/ seconds | up to 2 weeks after recruitment. estimation time of the outcome is 10 minutes. |
| Dizziness handicap inventory | A questionnaire filled out by the participant, assesses subjectively the level of dizziness from which the patient suffers. Score varies between 0-100 | up to 2 weeks after recruitment. estimation time of the outcome is 5 minutes. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Miki Paker, MD | haemek medical center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hemek Medical center | Afula | 1834111 | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17310004 | Background | Pariser DM, Bagel J, Gelfand JM, Korman NJ, Ritchlin CT, Strober BE, Van Voorhees AS, Young M, Rittenberg S, Lebwohl MG, Horn EJ; National Psoriasis Foundation. National Psoriasis Foundation clinical consensus on disease severity. Arch Dermatol. 2007 Feb;143(2):239-42. doi: 10.1001/archderm.143.2.239. | |
| 17075400 | Background |
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The individual participant data will be collected in the principal investigator computer for a period of 7 years.
The computer has a personal password and the computer if located inside a locked room.
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| ID | Term |
|---|---|
| D011565 | Psoriasis |
| ID | Term |
|---|---|
| D017444 | Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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the participants are divided into 2 groups: psoriatic patients and healthy volunteers.
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| Halligan CS, Bauch CD, Brey RH, Achenbach SJ, Bamlet WR, McDonald TJ, Matteson EL. Hearing loss in rheumatoid arthritis. Laryngoscope. 2006 Nov;116(11):2044-9. doi: 10.1097/01.mlg.0000241365.54017.32. |
| 17409782 | Background | Bayazit YA, Yilmaz M, Gunduz B, Altinyay S, Kemaloglu YK, Onder M, Gurer MA. Distortion product otoacoustic emission findings in Behcet's disease and rheumatoid arthritis. ORL J Otorhinolaryngol Relat Spec. 2007;69(4):233-8. doi: 10.1159/000101544. Epub 2007 Apr 4. |
| 17094003 | Background | Dagli M, Sivas Acar F, Karabulut H, Eryilmaz A, Erkol Inal E. Evaluation of hearing and cochlear function by DPOAE and audiometric tests in patients with ankylosing spondilitis. Rheumatol Int. 2007 Apr;27(6):511-6. doi: 10.1007/s00296-006-0249-6. Epub 2006 Nov 9. |
| 25687690 | Background | Yen YC, Lin YS, Weng SF, Lai FJ. Risk of sudden sensorineural hearing loss in patients with psoriasis: a retrospective cohort study. Am J Clin Dermatol. 2015 Jun;16(3):213-20. doi: 10.1007/s40257-015-0117-9. |
| 30280411 | Background | Vir D, Sharma P, Mahajan R, Dogra S, Bakshi J, Panda NK. Investigation of high-frequency hearing loss and outer hair cell function of the cochlea in patients with psoriasis: a case-control study. Clin Exp Dermatol. 2019 Jul;44(5):520-523. doi: 10.1111/ced.13805. Epub 2018 Oct 2. |