iPad Application-based Intervention for Post-stroke Depression

An iPad Application-based Intervention for Improving Post-stroke Depression Symptoms: A Pilot Randomized Controlled Trial

We plan to conduct a randomized controlled trial to examine whether usual rehabilitation plus an iPad application-based intervention improves post-stroke depression symptoms compared to usual rehabilitation alone.

The purpose of this pilot randomized controlled trial is to investigate the feasibility of the final randomized controlled trial.

Inclusion Criteria:

• 40 years and older
• Males and females
• Center for Epidemiologic Studies Depression Scale score ≥16
• Mini Mental State Examination score ≥ 24
• First stroke
• Native language is Japanese
• Written informed consent prior to participation

Exclusion Criteria:

• Major depressive disorder before onset of stroke
• Bilateral hemiplegia
• Vision or hearing deficits that negatively impact everyday life
• Severe aphasia
• Severe unilateral spatial neglect
• Diagnosis of neurodegenerative disease such as Parkinson's disease or multiple system atrophy
• Current life-threatening severe organ failure, musculoskeletal disorders, or cancer