Pressure Support and Positive End Expiratory Pressure During Spontaneous Breathing Trial

Impact of the Combination of Pressure Support and Positive End Expiratory Pressure During Spontaneous Breathing Trial Versus T-piece on the Time to Successful Extubation

The aim of this study is to assess if a bundle associating pressure support and positive end-expiratory pressure during spontaneous breathing trial and detection by T-piece of patients with high-risk of extubation failure can reduce the time to successful extubation in critically ill patients.

Inclusion Criteria:

• Patient 18 years old or more
• Intubated and ventilated in intensive care unit for more than 24 hours
• Patient ready for weaning evaluation
• Failure of a first T-piece SBT

Exclusion Criteria:

• Chronic neuromuscular disease
• Guillain-Barré Syndrome
• Central nervous system disease with consciousness disorder
• Tracheostomy
• Chronic disease with life expectancy less than 1 year
• Pregnancy, breast feeding
• Withholding life support regarding a reintubation
• Prisoner or patient interned in psychiatric hospital
• Guardianship
• Language barrier
• Lack of medical insurance
• Lack of the patient's consent (or of the next of kin where appropriate)
• Patient under an exclusion period after enrollment in another research study