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In this multicentric controlled study, we aims to evaluate effect of caffeine on mental performances during a sleep deprivation protocol. Genetic polymorphisms are considered as a covariable.
Coffee is the most consumed arousing substance in the world. Caffeine is used as a natural countermeasure to maintain the performance of sleep deprived subjects. However, the effectiveness of caffeine is characterized by a large individual variability, also observed on side effects. This variability could notably be related to polymorphisms of the adenosine receptor 2a gene (ADORA2A) and Tumor Necrosis Factor-alpha, a pro-inflammatory cytokine whose increase is observed during sleep deprivation.
This study, under conditions of total sleep deprivation in the laboratory (40 hours of continuous awakening), examine the cross-influence of two polymorphisms (ADORA2A: rs5751876 and TNF-alpha: rs1800629) on the sensitivity to caffeine and on the degradation of attentional performances. Physical performance, mental performance, immuno-inflammatory responses and the occurrence indesirable effects will be evaluate.
This work aims to understand the mechanisms that contribute to increasing individual vulnerability and promoting protective countermeasures. The purpose of this project is to improve the recommendations concerning the daily use of caffeine and during periods of prolonged awakening, particularly in the military environment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Caffeine | Experimental | Caffeine 5 mg/kg/day in 2 administration (08:00 and 14:00) per day |
|
| placebo | Placebo Comparator | in 2 administration (08:00 and 14:00) per day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sleep deprivation | Other | 40 hours of continuous awaking in the sleep laboratory in order to compare before and after sleep deprivation for each treatment (Caffeine vs. placebo). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Psychomotor vigilance test Speed | Speed at the Psychomotor vigilance test test | Change from Baseline Psychomotor vigilance test Speed at day 2 after 24 hours awaking |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive performance | Number of errors at executive performance test | Change from Baseline at day 2 after 25 hours awaking |
| Force -velocity | Power at the force-velocity test |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut de recherche biomedical des armées | Brétigny-sur-Orge | France | ||||
| Hotel Dieu |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41694313 | Derived | Mateo L, Tardo-Dino PE, Gomez-Merino D, Drogou C, Josse PE, Erblang M, Colin P, Erkel MC, Van Beers P, Leger D, Bourrilhon C, Chennaoui M, Sauvet F. Both acute and chronic caffeine consumption affect cardiovascular responses to total sleep deprivation. Front Cardiovasc Med. 2026 Jan 30;13:1718154. doi: 10.3389/fcvm.2026.1718154. eCollection 2026. | |
| 40150834 |
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| ID | Term |
|---|---|
| D012892 | Sleep Deprivation |
| ID | Term |
|---|---|
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
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| Change from Baseline at day 2 after 32 hours awaking |
| Paris |
| 75004 |
| France |
| de Lorgeril B, Tardo-Dino PE, Bourrilhon C, Quiquempoix M, Drogou C, Mateo L, Erblang M, Colin P, Van Beers P, Chennaoui M, Gomez-Merino D, Sauvet F. Impact of acute caffeine intake on local tolerance to cold before and after total sleep deprivation. Exp Physiol. 2025 Sep;110(9):1254-1270. doi: 10.1113/EP092356. Epub 2025 Mar 27. |
| 39458438 | Derived | Pauchon B, Beauchamps V, Gomez-Merino D, Erblang M, Drogou C, Beers PV, Guillard M, Quiquempoix M, Leger D, Chennaoui M, Sauvet F. Caffeine Intake Alters Recovery Sleep after Sleep Deprivation. Nutrients. 2024 Oct 11;16(20):3442. doi: 10.3390/nu16203442. |
| 37279709 | Derived | Drogou C, Sauvet F, Erblang M, Leger D, Thomas C, Chennaoui M, Gomez-Merino D; Investigators group. Effects of Acute Caffeine Intake on Insulin-Like Growth Factor-1 Responses to Total Sleep Deprivation: Interactions with COMT Polymorphism - A Randomized, Crossover Study. Lifestyle Genom. 2023;16(1):113-123. doi: 10.1159/000529897. Epub 2023 Jun 6. |
| 34685481 | Derived | Erblang M, Drogou C, Gomez-Merino D, Rabat A, Guillard M, Beers PV, Quiquempoix M, Boland A, Deleuze JF, Olaso R, Derbois C, Prost M, Dorey R, Leger D, Thomas C, Chennaoui M, Sauvet F. Genetics and Cognitive Vulnerability to Sleep Deprivation in Healthy Subjects: Interaction of ADORA2A, TNF-alpha and COMT Polymorphisms. Life (Basel). 2021 Oct 19;11(10):1110. doi: 10.3390/life11101110. |
| 33920292 | Derived | Erblang M, Sauvet F, Drogou C, Quiquempoix M, Van Beers P, Guillard M, Rabat A, Trignol A, Bourrilhon C, Erkel MC, Leger D, Thomas C, Gomez-Merino D, Chennaoui M. Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882). Genes (Basel). 2021 Apr 10;12(4):555. doi: 10.3390/genes12040555. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |