Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Moderate intensity strength training has been shown to improve strength and mobility in persons with MS. It was suggested that whole-body vibration training (WBVT) is effective to improve muscle strength, such as resistance training, resulting from both neural and structural adaptations. On the other hand, traditional strength training in hypoxia has garnered much attention. This method has shown improvements in isometric strength and increases in muscle size.

• Crossover.
• 13 patients with multiple sclerosis were recruited.
• Patients performed two sessions: whole-body vibration training in normoxia condition and whole-body vibration in hypoxia condition.

Inclusion Criteria:

• mild or moderate disability with clinical mild spastic-ataxic gait disorder.
• stable phase of the disease.

Exclusion Criteria:

• Expanded Disability Status Scale (EDSS) < 6.
• relapsing disease within the preceding 12 months.
• corticosteroid treatment within the last months before study inclusion.