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due to personal changes
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This study is to describe the incidence of infectious meningitis and/or encephalitis, and to analyze clinical, diagnostic and treatment characteristics of patients with suspected (and subsequently verified and not verified) infection.
The specific aims of the study include:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| collection of patient data | Other | Patient data will be obtained using digital patients records systems. The following data will be assessed: Demographics and baseline patient characteristics (e.g., gender, age, hospital admission and discharge dates), diagnoses, comorbidities (history of meningitis and/or encephalitis, epileptic disorders, remote stroke, remote intracranial bleeding, remote autoimmune disease, neurodegenerative disorders), laboratory features (blood cultures, lumbar puncture), features of neuroimaging (e.g., time admission-to-CT), therapeutic features (incl. time admission-to-treatment), Patients' outcome measures (Glasgow Outcome Score) |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of patients with suspected and confirmed ME (number) | assessment of number of patients with suspected and confirmed ME | single time point assessment during hospital stay (up to 4 weeks) |
| Pathologic CT findings | assessment of number of patients with pathologic CT findings | single time point assessment during hospital stay (up to 4 weeks) |
| Pathologic CT findings constituting a risk factor for herniation after performance of LP | assessment of number of patients with pathologic CT findings constituting a risk factor for herniation after performance of LP | single time point assessment during hospital stay (up to 4 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| hematoma (number) | hematoma as a complication of LP | single time point assessment during hospital stay (up to 4 weeks) |
| Glasgow Outcome Score | scale of patients with brain injuries that groups victims by the objective degree of recovery.The scale consists of five ordinal outcome categories: good recovery (able to live independently, able to return to work or school), moderate disability (able to live independently, unable to return to work or school), severe disability (able to follow commands, unable to live independently), persistent vegetative state (unable to interact with the environment, unresponsive), and death. |
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Inclusion Criteria:
Exclusion Criteria:
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All patients admitted to the University Hospital Basel with suspected or confirmed infectious meningitis/encephalitis over a 10-year period (from January 2006 to December 2021).
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| Name | Affiliation | Role |
|---|---|---|
| Raoul Sutter, PD Dr. med | Clinic for Intensive Care Medicine, University Hospital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinic for Intensive Care Medicine, University Hospital Basel | Basel | 4031 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32326881 | Derived | Dittrich T, Marsch S, Egli A, Ruegg S, De Marchis GM, Tschudin-Sutter S, Sutter R. Predictors of infectious meningitis or encephalitis: the yield of cerebrospinal fluid in a cross-sectional study. BMC Infect Dis. 2020 Apr 23;20(1):304. doi: 10.1186/s12879-020-05022-6. |
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| ID | Term |
|---|---|
| D008581 | Meningitis |
| D004660 | Encephalitis |
| ID | Term |
|---|---|
| D000090862 | Neuroinflammatory Diseases |
| D009422 | Nervous System Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| single time point assessment during hospital stay (up to 4 weeks) |
| postpuncture headache (number) | postpuncture headache as a complication of LP | single time point assessment during hospital stay (up to 4 weeks) |
| cerebral herniation (number) | cerebral herniation as a complication of LP | single time point assessment during hospital stay (up to 4 weeks) |
| pathological CT findings (number) | number and evaluation of pathological CT findings (especially expanding cerebral mass lesions) in patients with suspected infectious ME | single time point assessment at hospitalisation (Day1) |
| kind of medication | assessment of medication (treatment characteristics ) of patients with suspected and confirmed ME | single time point assessment during hospital stay (up to 4 weeks) |
| Intensive Care Delirium Screening Checklist (ICDSC) | The ICDSC is a screening instrument including eight items specifically designed for the intensive care setting with two points: absent or present. The items include the assessment of: (1) consciousness (comatose, soporose, awake, or hypervigilant); (2) orientation; (3) hallucinations or delusions; (4) psychomotor activity; (5) inappropriate speech or mood; (6) attentiveness; (7) sleep-wake cycle disturbances; and (8) fluctuation of symptomatology. The maximum score is eight; scores of ≥4 indicate the presence of Delirium. | single time point assessment during hospital stay (up to 4 weeks) |
| Death during hospital stay | assessment of number of patients with in-hospital death | single time point assessment during hospital stay (up to 4 weeks) |
| Return to premorbid functional baseline | assessment of number of patients with return to premorbid functional baseline | single time point assessment during hospital stay (up to 4 weeks) |