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| Name | Class |
|---|---|
| Beijing Shijitan Hospital, Capital Medical University | OTHER |
| The Affiliated Hospital Of Southwest Medical University | OTHER |
| Zhejiang Provincial People's Hospital | OTHER |
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According to the patient's blood management concept, this study intends to collect basic information, surgical data, blood transfusion related data and patient prognosis data of patients with pelvic fractures, and to construct a predictive model of intraoperative blood transfusion in patients with pelvic fractures by multiple linear regression analysis. To guide physicians use blood accurately during surgery. Prompt doctors to reduce blood transfusion dose and improve patient prognosis by stopping bleeding and blood recovery before surgery.
2.1 Research Objectives: This study aims to construct a blood transfusion model for pelvic fractures, to guide the rational use of blood during surgery, and to improve the prognosis of patients.
2.2 Research content: 2.2.1 Collect basic data, surgical data, blood transfusion related data and patient prognosis related data of patients with pelvic fractures.
2.2.2 Gradually incorporate and exclude data from multiple linear regression models.
2.2.3 Verify the specificity and sensitivity of the intraoperative blood transfusion prediction model.
2.2.4 Create a visualization window to guide clinical blood. 2.2.5 Put into clinical trial and feedback, and continue to verify 2.3 Key issues to be resolved 2.3.1 The factors related to intraoperative blood transfusion in patients with pelvic fractures (such as blood oxygenation, blood loss, HB value, intraoperative autologous blood recovery, blood pressure, heart rate, etc.) were initially screened by univariate analysis.
2.3.2 Reasonably standardize the objective and subjective indicators of different units and different institutions.
2.4 Expected research results Intraoperative blood transfusion prediction model and window for patients with pelvic fractures.
2.5 Assessment indicators Published 1-2 papers. Create a visual applet and put it into trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pelvic fracture patients | (1) 1\ |
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| Measure | Description | Time Frame |
|---|---|---|
| Matta Radiographic Scoring | Reductions were graded by the maximal displacement measured on the 3 standard views of the pelvis. Criteria were: excellent 4 mm or less, good 5 to 10 mm, fair 10 to 20 mm, and poor more than 20 mm. | 6 months of postoperation |
| Mortality | Mortality during hospitalization | 24 hours after the Patients' Hospitalization |
| Measure | Description | Time Frame |
|---|---|---|
| Hb difference | Hb difference before and after transfusion | 24 hours after transfusion |
| Pain assessed by the VAS | Change in the Pain Intensity Score (0-10 NRS) |
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Inclusion Criteria:
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Patients with pelvic fractures who meet the standard in China, 1\
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rong Gui, Ph.D | Contact | 13975199279 | aguirong@163.com | |
| Huang Xueyuan, Mater degree | Contact | 15273157184 | 2458481936@qq.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Third Xiangya Hospital | Recruiting | Changsha | Hunan | 410013 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19952241 | Background | Sathy AK, Starr AJ, Smith WR, Elliott A, Agudelo J, Reinert CM, Minei JP. The effect of pelvic fracture on mortality after trauma: an analysis of 63,000 trauma patients. J Bone Joint Surg Am. 2009 Dec;91(12):2803-10. doi: 10.2106/JBJS.H.00598. | |
| 25086126 | Background | Perkins ZB, Maytham GD, Koers L, Bates P, Brohi K, Tai NR. Impact on outcome of a targeted performance improvement programme in haemodynamically unstable patients with a pelvic fracture. Bone Joint J. 2014 Aug;96-B(8):1090-7. doi: 10.1302/0301-620X.96B8.33383. |
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| ID | Term |
|---|---|
| D006620 | Hip Fractures |
| D065227 | Transfusion Reaction |
| ID | Term |
|---|---|
| D005264 | Femoral Fractures |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
| D025981 | Hip Injuries |
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| Central South University |
| OTHER |
| Qilu Hospital of Shandong University | OTHER |
| Beijing Aerospace General Hospital | OTHER |
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| 15 minutes, 30 minutes, 1 hours, 2 hours, 4 hours, 6 hours, 12 hours, 18 hours, 24 hours postoperatively |
| Postoperative Duration of Stay in Hospital of patients | The postoperative duration of stay in hospital of patients between the restrictive transfusion group and the liberal transfusion group are compared. | 52 Weeks |
| 21063578 | Background | Santana-Cabrera L, Rodriguez Gonzalez F, Palacios MS. Delayed perforation of the sigmoid colon following a major pelvic fracture. J Emerg Trauma Shock. 2010 Oct;3(4):425-6. doi: 10.4103/0974-2700.70770. No abstract available. |
| 22168590 | Background | Carson JL, Terrin ML, Noveck H, Sanders DW, Chaitman BR, Rhoads GG, Nemo G, Dragert K, Beaupre L, Hildebrand K, Macaulay W, Lewis C, Cook DR, Dobbin G, Zakriya KJ, Apple FS, Horney RA, Magaziner J; FOCUS Investigators. Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med. 2011 Dec 29;365(26):2453-62. doi: 10.1056/NEJMoa1012452. Epub 2011 Dec 14. |
| 16617259 | Background | Nathens AB. Massive transfusion as a risk factor for acute lung injury: association or causation? Crit Care Med. 2006 May;34(5 Suppl):S144-50. doi: 10.1097/01.CCM.0000214309.95032.65. |
| 27865687 | Background | Ohmori T, Matsumoto T, Kitamura T, Tamura R, Tada K, Inoue T, Hayashi T, Numoto K, Tokioka T. Scoring system to predict hemorrhage in pelvic ring fracture. Orthop Traumatol Surg Res. 2016 Dec;102(8):1023-1028. doi: 10.1016/j.otsr.2016.09.007. Epub 2016 Nov 17. |
| 16766790 | Background | Hardy JF, de Moerloose P, Samama CM; Members of the Groupe d'Interet en Hemostase Perioperatoire. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth. 2006 Jun;53(6 Suppl):S40-58. doi: 10.1007/BF03022251. |
| D007869 |
| Leg Injuries |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007154 | Immune System Diseases |