A multi-center, multi-year registry of patients with gastroesophageal reflux disease (GERD) undergoing diagnostic evaluation and/or treatment of GERD and associated diseases and complications.

This registry is a prospective, multicenter registry of patients undergoing diagnostic evaluation and/or treatment of gastroesophageal reflux disease and associated diseases and complications.

Patients who are eligible will have disease and therapy-specific data collected throughout treatment and long-term (5-year) follow-up.

Electronic data capture via REDCap will be utilized for all sites.

Inclusion Criteria:

• Referred GERD patients willing to participate in long term follow-up (5 years)

Exclusion Criteria:

• Potential participants will be excluded if unwilling or unable to complete surveillance questionnaires through this registry

Patients referred by physicians having diagnostic evaluation or treatment for GERD.

Research projects will be submitted to host (currently JHU) and accepted project will be granted access to read only de-identified database.

minimum 6 years

Project submission to PI and or Heartburn Registry management team then if project accepted, security clearance and enrollment in REDCap and tutorial completions.