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This study evaluated the effectiveness of socket grafting material, combination of plate-rich fibrin and calcium sulfate. 5 subjects were grafted with this material, 5 subjects were grafted with combination of plate-rich fibrin and xenograft.
Calcium sulfate (CS), an alloplastic material, is widely accepted as a socket grafting material and undergoes rapid and complete resorption. Studies have shown that CS creates an osteoconductive lattice that stimulates bone ingrowth into a defect. PRF poses multiple growth factors, anti-inflammatory cytokines and adhesion molecules. It is biologically active up to one week. The combination of these 2 materials will serve as good grafting material for tooth socket, in order to preserve vertical and horizontal dimensions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| test (PRF-CS) | Experimental | After atraumatic tooth extraction, the socket was gently curettage and irrigated with saline. Combination of platelet-rich fibrin and calcium sulfate was placed into the socket followed by a PRF plug . Black silk suture (3-0) was placed on mesial, mid and distal using simple interrupted technique. |
|
| control (PRF-X) | Active Comparator | After atraumatic tooth extraction, the socket was gently curettage and irrigated with saline. Combination of platelet-rich fibrin and xenograft (MinerOss® X) was placed into the socket followed by a PRF plug . Black silk suture (3-0) was placed on mesial, mid and distal using simple interrupted technique. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| platelet-rich fibrin and calcium sulfate | Combination Product |
| ||
| platelet-rich fibrin and xenograft |
| Measure | Description | Time Frame |
|---|---|---|
| vertical dimension at baseline | measurements were done on radiograph (CBCT) images | before extraction |
| horizontal dimension at baseline | measurements were done on radiograph (CBCT) images | before extraction |
| soft tissue level at baseline | measurements were done on stone models | before extraction |
| volume at baseline | measurements were done on radiograph (CBCT) images | before extraction |
| Measure | Description | Time Frame |
|---|---|---|
| vertical dimension after extraction | measurements were done on radiograph (CBCT) images | five months after extraction |
| horizontal dimension after extraction | measurements were done on radiograph (CBCT) images |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| CHIA W CHEAH | University of Malaya | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15691354 | Background | Araujo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005 Feb;32(2):212-8. doi: 10.1111/j.1600-051X.2005.00642.x. | |
| 19885449 | Background | Darby I, Chen ST, Buser D. Ridge preservation techniques for implant therapy. Int J Oral Maxillofac Implants. 2009;24 Suppl:260-71. |
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socio demographic background
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Oct 24, 2018 | Feb 21, 2019 | Prot_SAP_001.pdf |
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| ID | Term |
|---|---|
| D002133 | Calcium Sulfate |
| D014183 | Transplantation, Heterologous |
| ID | Term |
|---|---|
| D017610 | Calcium Compounds |
| D007287 | Inorganic Chemicals |
| D008903 | Minerals |
| D013431 | Sulfates |
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| Combination Product |
|
| five months after extraction |
| soft tissue level after extraction | measurements were done on stone models | five months after extraction |
| volume after extraction | measurements were done on radiograph (CBCT) images | five months after extraction |
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| D013464 |
| Sulfuric Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
| D014180 | Transplantation |
| D013514 | Surgical Procedures, Operative |