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| ID | Type | Description | Link |
|---|---|---|---|
| 2018-002574-52 | EudraCT Number | ||
| 2022-502380-37-00 | Other Identifier | EU CT |
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This study evaluates the duration of intraocular pressure (IOP)-lowering effect and safety of as needed administrations of Bimatoprost sustained release (SR) in participants with open-angle glaucoma (OAG) or ocular hypertension (OHT) who are not adequately managed with topical IOP-lowering medication for reasons other than medication efficacy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bimatoprost SR - Dose A | Experimental | Study Eye: Participants will receive 1 - 2 Cycles of Bimatoprost SR administrations of Dose A Fellow Eye: The eye that does not receive Bimatoprost SR treatment will receive standard of care or up to one administration of Bimatoprost SR. |
|
| Bimatoprost SR - Dose B | Experimental | Study Eye: Participants received 1 - 3 Cycles of Bimatoprost SR administrations of Dose B Fellow Eye: The eye that does not receive Bimatoprost SR treatment will receive standard of care or up to one administration of Bimatoprost SR. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bimatoprost (SR) | Drug | Study Eye: Cycles 1 - 3 administrations through the PRN treatment period. Fellow Eye: Standard of care or Bimatoprost SR. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Retreatment or rescue administered for IOP | Treatment modality determined by investigator. | Up to 48 months |
| Number of patients experiencing a treatment emergent adverse event | The number of patients who experienced one or more TEAE during the 48 month treatment period. | Baseline up to 48 months |
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Inclusion Criteria:
- Diagnosis of either open angle glaucoma (OAG) (i.e., primary OAG, pseudoexfoliation glaucoma, pigmentary glaucoma) or ocular hypertension requiring intraocular pressure-lowering treatment.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| ABBVIE INC. | AbbVie | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Horizon Eye Specialists & Lasik Centers /ID# 235240 | Sun City | Arizona | 85351 | United States | ||
| Atlantis Eye Care /ID# 235530 |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39985740 | Derived | Silverstein SM, Oddone F, Kolko M, Brinkmann CK, Christie WC, Bicket AK, Gous PNJ, Luebke J, Maram J, Nguyen A, Craven ER, Pu Y, Jiao J, Bejanian M, Robinson MR; TRITON Study Group. Safety and Longevity of Intraocular Pressure Control After Bimatoprost Implant Administration: Interim Analysis of a Phase 3b Clinical Trial (TRITON). Drugs. 2025 Apr;85(4):557-570. doi: 10.1007/s40265-025-02154-4. Epub 2025 Feb 22. |
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AbbVie is committed to responsible clinical trial data sharing. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information.
For details on when studies are available for sharing visit https://vivli.org/ourmember/abbvie/
To learn more about the process, or to submit a request, visit the following link https://www.abbvieclinicaltrials.com/hcp/data-sharing/
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| Huntington Beach |
| California |
| 92647 |
| United States |
| Lakeside Vision Center /ID# 234970 | Irvine | California | 92604 | United States |
| Global Research Foundation /ID# 237350 | Los Angeles | California | 90041-1718 | United States |
| The Eye Research Foundation /ID# 234521 | Newport Beach | California | 92663-3637 | United States |
| Byers Eye Institute Stanford /ID# 235544 | Palo Alto | California | 94303 | United States |
| Foothill Eye Institute /ID# 235640 | Pasadena | California | 91107 | United States |
| Connecticut Eye Consultants P.C. /ID# 234981 | Danbury | Connecticut | 06810 | United States |
| Advanced Research, LLC /ID# 236045 | Deerfield Beach | Florida | 33064-1342 | United States |
| Segal Drug Trials, Inc /ID# 235784 | Delray Beach | Florida | 33484 | United States |
| International Research Center /ID# 238050 | Tampa | Florida | 33603 | United States |
| Thomas Eye Group PC /ID# 235737 | Sandy Springs | Georgia | 30328 | United States |
| Indiana University - Glick Eye Institute /ID# 235886 | Indianapolis | Indiana | 46202 | United States |
| Retina Partners Midwest, PC /ID# 237876 | Indianapolis | Indiana | 46290 | United States |
| Tulane University School of Medicine /ID# 237632 | New Orleans | Louisiana | 70112 | United States |
| Ophthalmic Consultants of Boston /ID# 236534 | Boston | Massachusetts | 02129 | United States |
| Clinical Eye Research of Boston LLC /ID# 234966 | Winchester | Massachusetts | 01890 | United States |
| University of Michigan, Kellogg Eye Center /ID# 236496 | Ann Arbor | Michigan | 48105 | United States |
| Fraser Eye Center /ID# 235790 | Fraser | Michigan | 48026 | United States |
| Silverstein Eye Centers /ID# 237881 | Kansas City | Missouri | 64034 | United States |
| Moyes Eye Centers /ID# 234989 | Kansas City | Missouri | 64154 | United States |
| Alterman Modi & Wolter /ID# 235248 | Poughkeepsie | New York | 12603-2455 | United States |
| The Ohio State University /ID# 236790 | Columbus | Ohio | 43210-1257 | United States |
| AMA Eyes Research Institute /ID# 235542 | Marysville | Ohio | 43040 | United States |
| Dean McGee Eye Institute /ID# 236823 | Oklahoma City | Oklahoma | 73104 | United States |
| Oklahoma Eye Surgeons /ID# 235849 | Oklahoma City | Oklahoma | 73112 | United States |
| Drs Fine Hoffman & Sims LLC /ID# 235918 | Eugene | Oregon | 97401 | United States |
| Ophthalmic Partners, PC /ID# 235741 | Bala-Cynwyd | Pennsylvania | 19004 | United States |
| Scott and Christie and Associates /ID# 234593 | Cranberry Township | Pennsylvania | 16066 | United States |
| Black Hills Regional Eye Institute /ID# 235075 | Rapid City | South Dakota | 57701 | United States |
| Vance Thompson Vision /ID# 235072 | Sioux Falls | South Dakota | 57108 | United States |
| Eye Specialty Group /ID# 235721 | Memphis | Tennessee | 38120 | United States |
| Vanderbilt University Medical Center /ID# 237177 | Nashville | Tennessee | 37232-0011 | United States |
| Advancing Vision Research /ID# 236681 | Smyrna | Tennessee | 37167 | United States |
| ATX Clinical Trials Inc. dba Keystone Research /ID# 235868 | Austin | Texas | 78731 | United States |
| Medical Center Ophthalmology Associates - Keystone Research /ID# 235787 | San Antonio | Texas | 78240 | United States |
| Southern Utah Medical Research /ID# 235602 | St. George | Utah | 84790 | United States |
| Piedmont Eye Center /ID# 234534 | Lynchburg | Virginia | 24502 | United States |
| Consultorio Oftalmologico Dr. Fabian Lerner /ID# 235855 | CABA | Buenos Aires | 1122 | Argentina |
| Hospital Universitario Austral /ID# 237727 | Pilar | Buenos Aires | 1629 | Argentina |
| Centro oftalmologico Dr Charles /ID# 235881 | Ciudad de Buenos Aires | Buenos Aires F.D. | 1116 | Argentina |
| Oftalmología Global /ID# 239187 | Rosario | Santa Fe Province | 2000 | Argentina |
| Hospital Italiano /ID# 235851 | Buenos Aires | 1181 | Argentina |
| Centro Privado de Ojos /ID# 241283 | Ciudad Autonoma Buenos Aires | 1033 | Argentina |
| Oftar Mendoza /ID# 240535 | Mendoza | 1019 | Argentina |
| Eye Surgery Associates /ID# 235873 | East Melbourne | Victoria | 3002 | Australia |
| Multiprofile Hospital for Active Treatment "Lozenetz" /ID# 244053 | Sofiya | Sofia | 1407 | Bulgaria |
| Diagnostic Consultative Center Aleksandrovska /ID# 238105 | Sofiya | Sofia | 1431 | Bulgaria |
| Medical Center Oxycom Burgas /ID# 235580 | Burgas | 8008 | Bulgaria |
| UMHAT Sveti Georgi /ID# 237027 | Plovdiv | 4002 | Bulgaria |
| MHAT Hadzhi Dimitar /ID# 238248 | Sliven | 8800 | Bulgaria |
| MHAT Dr. Bratan Shukerov /ID# 235498 | Smolyan | 4700 | Bulgaria |
| Medical center for eye healt Focus Ltd /ID# 235575 | Sofia | 1303 | Bulgaria |
| Pentagram Eye Hospital /ID# 235813 | Sofia | 1309 | Bulgaria |
| Specialized Hospital for Active Treatment in Ocular Diseases "Zrenie" /ID# 235500 | Sofia | 1408 | Bulgaria |
| St. Sofia Hospital /ID# 235525 | Sofia | 1618 | Bulgaria |
| Medical Center -Verea /ID# 235494 | Stara Zagora | 6000 | Bulgaria |
| Medical center Orfey /ID# 237344 | Stara Zagora | 6000 | Bulgaria |
| MHAT Trakia /ID# 238137 | Stara Zagora | 6004 | Bulgaria |
| Specialized Ophthalmological Hospital for Active Treatment - Varna /ID# 235962 | Varna | 9002 | Bulgaria |
| Všeobecná Fakultní Nemocnice v Praze /ID# 234422 | Prague | Praha 17 | 128 00 | Czechia |
| Ocni klinika Pardubice /ID# 235944 | Pardubice | 530 02 | Czechia |
| Fakultni nemocnice Kralovske Vinohrady /ID# 234323 | Prague | 100 34 | Czechia |
| Rigshospitalet Glostrup /ID# 235743 | Glostrup Municipality | Capital Region | 2600 | Denmark |
| Universitatsklinikum Freiburg /ID# 238048 | Freiburg im Breisgau | Baden-Wurttemberg | 79106 | Germany |
| Universitaetsmedizin Goettingen /ID# 237377 | Göttingen | Lower Saxony | 37075 | Germany |
| Universitaetsmedizin Rostock /ID# 237263 | Rostock | Mecklenburg-Vorpommern | 18057 | Germany |
| Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 237069 | Kiel | Schleswig-Holstein | 24105 | Germany |
| Klinikum Dresden Friedrichstadt /ID# 235308 | Dresden | 01067 | Germany |
| Asklepios Kinik Nord - Heidberg Augenklinik /ID# 235955 | Hamburg | 22417 | Germany |
| St. Franziskus-Hospital /ID# 237714 | Münster | 48145 | Germany |
| Dietrich-Bonhoeffer-Klinikum /ID# 235262 | Neubrandenburg | 17036 | Germany |
| Augenzentrum Dr Hamacher /ID# 235537 | Starnberg | 82319 | Germany |
| Gyongyosi Bugat Pal Korhaz /ID# 238144 | Gyöngyös | Heves County | 3200 | Hungary |
| Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 237383 | Szombathely | Vas County | 9700 | Hungary |
| Budapest Retina Intezet /ID# 235950 | Budapest | 1133 | Hungary |
| Jahn Ferenc Del-pesti Korhaz es Rendelointezet /ID# 237111 | Budapest | 1204 | Hungary |
| Royal Victoria Eye and Ear Hospital /ID# 235546 | Dublin | 2 | Ireland |
| Institute of Eye Surgery /ID# 235547 | Waterford | X91 DH9W | Ireland |
| University of Catanzaro /ID# 238066 | Catanzaro | Calabria | 88100 | Italy |
| Sapienza University of Rome - Polo Pontino /ID# 237451 | Terracina | Latina | 04019 | Italy |
| Duplicate_Eye Clinic University of Catania /ID# 235573 | Catania | 95123 | Italy |
| Duplicate_Ospedale Ss. Annunziata /ID# 236587 | Chieti | 66100 | Italy |
| Fondazione IRCCS Policlinico San Matteo /ID# 236909 | Pavia | 27100 | Italy |
| University of Perugia /ID# 235811 | Perugia | 06156 | Italy |
| Fondazione Bietti - Ospedale Britannico /ID# 235495 | Rome | 00184 | Italy |
| Southern Eye Specialists /ID# 236080 | Christchurch | Canterbury | 8013 | New Zealand |
| Capital Eye Specialists /ID# 236112 | Wellington | 6011 | New Zealand |
| Wojskowy Instytut Medyczny /ID# 237031 | Warsaw | Masovian Voivodeship | 04-349 | Poland |
| Optimum Profesorskie Centrum Okulistyki SP.z.o.o. /ID# 237076 | Gdansk | Pomeranian Voivodeship | 80-809 | Poland |
| Centrum Diagnostyki i Mikrochirurgii Oka - LENS sp. z o.o /ID# 235928 | Olsztyn | Warmian-Masurian Voivodeship | 10-424 | Poland |
| Gabinet Okulistyczny Edward Wylegala /ID# 235946 | Katowice | 40-594 | Poland |
| Medical Center Julianow /ID# 235961 | Lodz | Łódź Voivodeship | 91-485 | Poland |
| S. Fyodorov Eye Microsurgery Federal State Institution /ID# 235984 | Novosibirsk | Novosibirsk Oblast | 630071 | Russia |
| Pretoria Eye Institute - Private Practice /ID# 235658 | Pretoria | Gauteng | 0083 | South Africa |
| Somerset Eye Specialist Medical & Surgical Centre /ID# 235540 | Somerset West | Western Cape | 7130 | South Africa |
| Norrlands University hospital /ID# 237553 | Umeå | Västerbotten County | 581 85 | Sweden |
| Addenbrookes Hospital /ID# 238255 | Cambridge | Cambridgeshire | CB2 2QQ | United Kingdom |
| Mid Essex Hospitals NHS Trust /ID# 237776 | Chelmsford | Essex | CM1 7ET | United Kingdom |
| The Princess Alexandra NHS Trust /ID# 234433 | Harlow | Essex | CM20 1QX | United Kingdom |
| Kings College Hospital NHS Foundation Trust /ID# 237275 | London | Greater London | SE5 9RS | United Kingdom |
| York Hospital /ID# 237683 | York | North Yorkshire | YO31 8HE | United Kingdom |
| Oxford University Hospitals NHS Foundation Trust /ID# 237282 | Oxford | Oxfordshire | OX3 9DU | United Kingdom |
| East Suffolk and North Essex NHS Foundation Trust /ID# 234657 | Colchester | CO4 5JL | United Kingdom |
| Mid-Cheshire Hospitals NHS Trust /ID# 235418 | Crewe | CW1 4QJ | United Kingdom |
| Liverpool University Hospitals NHS Foundation Trust /ID# 237095 | Liverpool | L7 8XP | United Kingdom |
| Liverpool University Hospitals NHS Foundation Trust /ID# 237321 | Liverpool | L7 8XP | United Kingdom |
| Central Middlesex Hospital /ID# 236216 | London | NW10 7NS | United Kingdom |
| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| D009798 | Ocular Hypertension |
| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D000069580 | Bimatoprost |
| ID | Term |
|---|---|
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D003008 | Cloprostenol |
| D011461 | Prostaglandins F, Synthetic |
| D011465 | Prostaglandins, Synthetic |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |
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